Avortements spontanés à répétition

Merviel, Philippe; Lanta, S.; Allier, Gabriel; Gagneur, O.; Najas, S; Nasreddine, A.; Campy, H.; Naepels, P.; Gondry, J.; Boulanger, J. C.

doi:10.1016/j.emcgo.2005.04.004

Cited by 3 publications

(3 citation statements)

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“…1,2 Current important applications of D-amino acids include their use as key components in b-lactam antibiotics, fertility drugs, anticoagulants, and pesticides. 1,[3][4][5] D-Arylalanines, such as D-phenylalanine (D-Phe), are useful intermediates for the production of pharmaceuticals, including b-lactam antibiotics, small peptide hormones, and pesticides. 4 The production of D-Phe is of great interest since pharmaceuticals that include analgesics, antistress agents, antidiabetics (e.g., nateglinide), and anticoagulants are synthesized from D-arylalanines.…”

Section: Introductionmentioning

confidence: 99%

Highly selective synthesis of d-amino acids from readily available l-amino acids by a one-pot biocatalytic stereoinversion cascade

et al. 2019

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Section: Introductionmentioning

confidence: 99%

Highly selective synthesis of d-amino acids from readily available l-amino acids by a one-pot biocatalytic stereoinversion cascade

et al. 2019

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“…d -Amino acids are increasingly becoming important building blocks in the production of pharmaceuticals and fine chemicals, and as chiral directing auxiliaries and chiral synthons in organic synthesis. Current important applications of d -amino acids include their use as key components in β-lactam antibiotics, fertility drugs, anticoagulants, and pesticides . For example, two important d -amino acids used in semisynthetic antibiotics, d -phenylglycine (ampicillin), and p -hydroxy- d -phenylglycine (amoxicillin) are currently produced on a scale >5000 tons per year worldwide .…”

Section: Introductionmentioning

confidence: 99%

Creation of a Broad-Range and Highly Stereoselectived-Amino Acid Dehydrogenase for the One-Step Synthesis ofd-Amino Acids

Vedha-Peters¹,

Gunawardana²,

Rozzell³

et al. 2006

J. Am. Chem. Soc.

121

117

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Using both rational and random mutagenesis, we have created the first known broad substrate range, nicotinamide cofactor dependent, and highly stereoselective D-amino acid dehydrogenase. This new enzyme is capable of producing D-amino acids via the reductive amination of the corresponding 2-keto acid with ammonia. This biocatalyst was the result of three rounds of mutagenesis and screening performed on the enzyme meso-diaminopimelate D-dehydrogenase. The first round targeted the active site of the wild-type enzyme and produced mutants that were no longer strictly dependent on the native substrate. The second and third rounds produced mutants that had an increased substrate range including straight-and branched-aliphatic amino acids and aromatic amino acids. The very high selectivity towards the D-enantiomer (95 to > 99% e.e) was shown to be preserved even after the addition of the five mutations found in the three rounds of mutagenesis and screening. This new enzyme could complement and improve upon current methods for D-amino acid synthesis.

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“…( R )-Amino acids are increasingly becoming important building blocks in the production of pharmaceuticals and fine chemicals and as chiral directing auxiliaries and chiral synthons in organic synthesis. Applications of ( R )-amino acids include their use as key components in β-lactam antibiotics, fertility drugs, and anticoagulants , …”

Section: Enzymatic Reductive Amination: Preparation Of (R)-amino Acid...mentioning

confidence: 99%

Biocatalysis: Synthesis of Key Intermediates for Development of Pharmaceuticals

Patel

2011

ACS Catal.

160

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Chirality is a key factor for the safety and efficacy of many drug products. The production of single enantiomers of drug intermediates has become increasingly important in the pharmaceutical industry. There has been an enormous potential of microorganisms and enzymes derived from there for the transformation of synthetic chemicals with high chemo-, regio-, and enatioselectivities. Recent development in the area of directed evolution has led screen mutants under process conditions to increase activity and selectivity of biocatalysts, thus making the enzymatic process highly efficient and economically feasible. In this review, chemoenzymatic processes are described for the synthesis of chiral intermediates for the development of pharmaceuticals.

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Avortements spontanés à répétition

Cited by 3 publications

References 113 publications

Highly selective synthesis of d-amino acids from readily available l-amino acids by a one-pot biocatalytic stereoinversion cascade

Highly selective synthesis of d-amino acids from readily available l-amino acids by a one-pot biocatalytic stereoinversion cascade

Creation of a Broad-Range and Highly Stereoselectived-Amino Acid Dehydrogenase for the One-Step Synthesis ofd-Amino Acids

Biocatalysis: Synthesis of Key Intermediates for Development of Pharmaceuticals

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