AVP dynamically increases paracellular Na+ permeability and transcellular NaCl transport in the medullary thick ascending limb of Henle’s loop

Himmerkus, Nina; Plain, Allein; Marques, Rita Delgado; Sonntag, Svenja Rebecca; Paliege, Alexander; Leipziger, Jens

doi:10.1007/s00424-016-1915-5

Cited by 16 publications

(16 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased sodium reabsorption in the TAL increases the tonicity of the interstitial space, which in turn favors the reabsorption of water in the CD. More recently, it was discovered that vasopressin can also increase sodium uptake via the paracellular route, possibly via claudin 10b [50]. Whether these recent findings on paracellular sodium transport could be beneficial in the search for possible treatment options for BS remains to be elucidated.…”

Section: Paracellular Sodium Absorption In the Talmentioning

confidence: 99%

Bartter and Gitelman syndromes: Questions of class

2019

View full text Add to dashboard Cite

Bartter and Gitelman syndromes are rare inherited tubulopathies characterized by hypokalaemic, hypochloraemic metabolic alkalosis. They are caused by mutations in at least 7 genes involved in the reabsorption of sodium in the thick ascending limb (TAL) of the loop of Henle and/or the distal convoluted tubule (DCT). Different subtypes can be distinguished and various classifications have been proposed based on clinical symptoms and/or the underlying genetic cause. Yet, the clinical phenotype can show remarkable variability, leading to potential divergences between classifications. These problems mostly relate to uncertainties over the role of the basolateral chloride exit channel CLCNKB, expressed in both TAL and DCT and to what degree the closely related paralogue CLCNKA can compensate for the loss of CLCNKB function. Here, we review what is known about the physiology of the transport proteins involved in these disorders. We also review the various proposed classifications and explain why a gene-based classification constitutes a pragmatic solution.

show abstract

Section: Paracellular Sodium Absorption In the Talmentioning

confidence: 99%

Bartter and Gitelman syndromes: Questions of class

2019

View full text Add to dashboard Cite

show abstract

“…The tight junctions reacted to ADH stimulation with a specific increase in Na + permeability. 42 These paracellular changes ideally support mTAL function. If paracellular Na + permeability increases, a moderate increase in transepithelial voltage results in a large increase in paracellular Na + current.…”

Section: Control Of Paracellular Na + Transport In the Talmentioning

confidence: 90%

“…The reason for this was a change in the paracellular properties by ADH. The tight junctions reacted to ADH stimulation with a specific increase in Na + permeability . These paracellular changes ideally support mTAL function.…”

Section: Control Of Paracellular Na+ Transport In the Talmentioning

confidence: 98%

See 1 more Smart Citation

Heterogeneity of tight junctions in the thick ascending limb

Wulfmeyer

Himmerkus

Milatz

2017

Annals of the New York Academy of Sciences

Self Cite

View full text Add to dashboard Cite

Renal tubular transport mechanisms are optimized to be energy efficient and tailored to local gradients and transport rates. The combined transcellular action of ion channels, transporters, and pumps, together with the paracellular pathway, enables kidney function. Monogenetic diseases and mouse models indicate that both trans- and paracellular proteins can become disease-causing candidates and may be targets for future therapeutic approaches. Recent advances in tight junction research have provided new insights into their structure, function, and regulation. The thick ascending limb (TAL) is a nephron segment with specific requirements for the paracellular pathway. It has to fuel the generation of the corticomedullary concentration gradient, to be watertight, and to provide a highly selective permeability for Na and divalent cations. Tight junction composition and function in the TAL is organized along the corticomedullary axis. Even on the level of a seemingly homogeneous tubular epithelium like the TAL, there is a separation of tight junction protein expression in the strands between the respective tricellular nexus of the junctional network. Here, we highlight some new insights from our recent work and that of others in this context. In addition, we provide some perspectives for the further study of paracellular transport mechanisms.

show abstract

“…Vasopressin increases paracellular Na + permeability in the mTAL ISOM . Whether this increase is related to alterations in CLDN10 regulation is unclear as no changes in CLDN10 expression were observed . Recently, patients with mutations in the CLDN10 gene have been identified .…”

Section: Axial and Cellular Heterogeneity Of Nacl Transport In Talmentioning

confidence: 99%

Axial and cellular heterogeneity in electrolyte transport pathways along the thick ascending limb

Dimke

Schnermann

2018

Acta Physiologica

View full text Add to dashboard Cite

The thick ascending limb (TAL) extends from the border of the inner medulla to the renal cortex, thus ascending through regions with wide differences in tissue solute and electrolyte concentrations. Structural and functional differences between TAL cells in the medulla (mTAL) and the cortex (cTAL) would therefore be useful to adapt TAL transport function to a changing external fluid composition. While mechanisms common to all TAL cells play a central role in the reclamation of about 25% of the NaCl filtered by the kidney, morphological features, Na / K -ATPase activity, NKCC2 splicing and phosphorylation do vary between segments and cells. The TAL contributes to K homeostasis and TAL cells with high or low basolateral K conductances have been identified which may be involved in K reabsorption and secretion respectively. Although transport rates for HCO3- do not differ between mTAL and cTAL, divergent axial and cellular expression of H transport proteins in TAL have been documented. The reabsorption of the divalent cations Ca and Mg is highest in cTAL and paralleled by differences in divalent cation permeability and the expression of select claudins. Morphologically, two cell types with different cell surface phenotypes have been described that still need to be linked to specific functional characteristics. The unique external environment and its change along the longitudinal axis require an axial functional heterogeneity for the TAL to optimally participate in conserving electrolyte homeostasis. Despite substantial progress in understanding TAL function, there are still considerable knowledge gaps that are just beginning to become bridged.

show abstract

AVP dynamically increases paracellular Na+ permeability and transcellular NaCl transport in the medullary thick ascending limb of Henle’s loop

Cited by 16 publications

References 53 publications

Bartter and Gitelman syndromes: Questions of class

Bartter and Gitelman syndromes: Questions of class

Heterogeneity of tight junctions in the thick ascending limb

Axial and cellular heterogeneity in electrolyte transport pathways along the thick ascending limb

Contact Info

Product

Resources

About