AVP neurons in the paraventricular nucleus of the hypothalamus regulate feeding

Pei, Hongjuan; Sutton, Amy K.; Burnett, Korri H.; Fuller, Patrick M.; Olson, David P.

doi:10.1016/j.molmet.2013.12.006

Cited by 114 publications

(89 citation statements)

References 25 publications

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“…Using multiple anatomical tracing techniques in Avp ires−Cre/+ mice (Pei et al, 2014), we confirmed that mouse VP pp neurons exhibited similar anatomical properties and that SON VP pp neurons did not send substantial collaterals to other brain areas (see Figure 1A, Figure S1, and Experimental Procedures).…”

Section: Resultssupporting

confidence: 52%

Bidirectional Anticipation of Future Osmotic Challenges by Vasopressin Neurons

Mandelblat-Cerf

Kim

Burgess

et al. 2017

Neuron

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SUMMARY Ingestion of water and food are major hypo- and hyperosmotic challenges. To protect the body from osmotic stress, posterior pituitary-projecting, vasopressin-secreting neurons (VPpp neurons) counter osmotic perturbations by altering their release of vasopressin, which controls renal water excretion. Vasopressin levels begin to fall within minutes of water consumption, even prior to changes in blood osmolality. To ascertain the precise temporal dynamics by which water or food ingestion affect VPpp neuron activity, we directly recorded the spiking and calcium activity of genetically defined VPpp neurons. In states of elevated osmolality, water availability rapidly decreased VPpp neuron activity within seconds, beginning prior to water ingestion, upon presentation of water-predicting cues. In contrast, food availability following food restriction rapidly increased VPpp neuron activity within seconds, but only following feeding onset. These rapid and distinct changes in activity during drinking and feeding suggest diverse neural mechanisms underlying anticipatory regulation of VPpp neurons.

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Section: Resultssupporting

confidence: 52%

Bidirectional Anticipation of Future Osmotic Challenges by Vasopressin Neurons

Mandelblat-Cerf

Kim

Burgess

et al. 2017

Neuron

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“…Therefore, an osmotic effect is unlikely to underlie the response of vasopressin or oxytocin neurones to SCM ingestion in our experiments. There is little evidence for a role of vasopressin neurones in appetite control (43,44). The mechanisms underlying a potential role of vasopressin in appetite control remains unknown; unlike oxytocin neurones, SON vasopressin neurones do not appear to be innervated by NTS projections and are inhibited by the satiety signal CCK (28).…”

Section: Discussionmentioning

confidence: 99%

High-Sugar, but Not High-Fat, Food Activates Supraoptic Nucleus Neurons in the Male Rat

2017

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Oxytocin is a potent anorexigen and is believed to have a role in satiety signaling. We developed rat models to study the activity of oxytocin neurons in response to voluntary consumption or oral gavage of foods using c-Fos immunohistochemistry and in vivo electrophysiology. Using c-Fos expression as an indirect marker of neural activation, we showed that the percentage of magnocellular oxytocin neurons expressing c-Fos increased with voluntary consumption of sweetened condensed milk (SCM). To model the effect of food in the stomach, we gavaged anesthetized rats with SCM. The percentage of supraoptic nucleus and paraventricular nucleus magnocellular oxytocin-immunoreactive neurons expressing c-Fos increased with SCM gavage but not with gastric distention. To further examine the activity of the supraoptic nucleus, we made in vivo electrophysiological recordings from SON neurons, where anesthetized rats were gavaged with SCM or single cream. Pharmacologically identified oxytocin neurons responded to SCM gavage with a linear, proportional, and sustained increase in firing rate, but cream gavage resulted in a transient reduction in firing rate. Blood glucose increased after SCM gavage but not cream gavage. Plasma osmolarity and plasma sodium were unchanged throughout. We show that in response to high-sugar, but not high-fat, food in the stomach, there is an increase in the activity of oxytocin neurons. This does not appear to be a consequence of stomach distention or changes in osmotic pressure. Our data suggest that the presence of specific foods with different macronutrient profiles in the stomach differentially regulates the activity of oxytocin neurons.

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“…The PVHpml predominantly contains oxytocin and vasopressin neurons (Simmons and Swanson, 2009). This is particularly interesting given that manipulations of either peptide interfere with the control of feeding behavior (e.g., Pei et al, 2014; see Olszewski et al, 2010 for review), and both are important for other forms of learning (Lahoud and Maroun, 2013; see Engelmann et al, 1996 for review). Our current findings that PVHpml neurons are recruited during tone-food learning indicate a potential role for PVH oxytocin and/or vasopressin function in appetitive associative learning and memory.…”

Section: Discussionmentioning

confidence: 99%

Appetitive associative learning recruits a distinct network with cortical, striatal, and hypothalamic regions

2015

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The amygdala, prefrontal cortex, striatum and other connected forebrain areas are important for reward-associated learning and subsequent behaviors. How these structurally and functionally dissociable regions are recruited during initial learning, however, is unclear. Recently, we showed amygdalar nuclei were differentially recruited across different stages of cue-food associations in a Pavlovian conditioning paradigm. Here, we systematically examined Fos induction in the forebrain, including areas associated with the amygdala, during early (day 1) and late (day 10) training sessions of cue-food conditioning. During training, rats in the conditioned group received tone-food pairings, while controls received presentations of the tone alone in the conditioning chamber followed by food delivery in their home cage. We found that a small subset of telencephalic and hypothalamic regions were differentially recruited during the early and late stages of training, suggesting evidence of learning induced plasticity. Initial tone-food pairings recruited solely the amygdala, while late tone-food pairings came to induce Fos in distinct areas within the medial and lateral prefrontal cortex, the dorsal striatum, and the hypothalamus (lateral hypothalamus and paraventricular nucleus). Furthermore, within the perifornical lateral hypothalamus, tone-food pairings selectively recruited neurons that produce the orexigenic neuropeptide orexin/hypocretin. These data show a functional map of the forebrain areas recruited by appetitive associative learning and dependent on experience. These selectively activated regions include interconnected prefrontal, striatal, and hypothalamic regions that form a discrete but distributed network that is well placed to simultaneously inform cortical (cognitive) processing and behavioral (motivational) control during cue-food learning.

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AVP neurons in the paraventricular nucleus of the hypothalamus regulate feeding

Cited by 114 publications

References 25 publications

Bidirectional Anticipation of Future Osmotic Challenges by Vasopressin Neurons

Bidirectional Anticipation of Future Osmotic Challenges by Vasopressin Neurons

High-Sugar, but Not High-Fat, Food Activates Supraoptic Nucleus Neurons in the Male Rat

Appetitive associative learning recruits a distinct network with cortical, striatal, and hypothalamic regions

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