Awake and behaving mouse fMRI during Go/No-Go task

Han, Zhe; Chen, Wenjing; Chen, Xifan; Zhang, Kaiwei; Tong, Chuanjun; Zhang, Xiaoxing; Li, C.; Liang, Zhifeng

doi:10.1016/j.neuroimage.2019.01.002

Cited by 78 publications

(100 citation statements)

References 65 publications

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“…One limitation of the present work is that the difference in states between behavioral testing (awake) and fMRI (anesthetized) might limit our ability to detect all potential neural correlates of the DBS therapeutic effect. For future studies, applications of awake rat fMRI 45 would be beneficial to provide more detailed clues of circuitry mechanisms of DBS therapies.…”

Section: Discussionmentioning

confidence: 99%

Full activation pattern mapping by simultaneous deep brain stimulation and fMRI with graphene fiber electrodes

et al. 2020

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Simultaneous deep brain stimulation (DBS) and functional magnetic resonance imaging (fMRI) constitutes a powerful tool for elucidating brain functional connectivity, and exploring neuromodulatory mechanisms of DBS therapies. Previous DBS-fMRI studies could not provide full activation pattern maps due to poor MRI compatibility of the DBS electrodes, which caused obstruction of large brain areas on MRI scans. Here, we fabricate graphene fiber (GF) electrodes with high charge-injection-capacity and little-to-no MRI artifact at 9.4T. DBS-fMRI with GF electrodes at the subthalamic nucleus (STN) in Parkinsonian rats reveal robust blood-oxygenation-level-dependent responses along the basal ganglia-thalamocortical network in a frequency-dependent manner, with responses from some regions not previously detectable. This full map indicates that STN-DBS modulates both motor and non-motor pathways, possibly through orthodromic and antidromic signal propagation. With the capability for full, unbiased activation pattern mapping, DBS-fMRI using GF electrodes can provide important insights into DBS therapeutic mechanisms in various neurological disorders.

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Section: Discussionmentioning

confidence: 99%

Full activation pattern mapping by simultaneous deep brain stimulation and fMRI with graphene fiber electrodes

et al. 2020

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“…We used ICA to remove non-neural artefacts potentially related to motion, breathing, heartbeats, and/or scanner instability from spatially co-registered data. ICAbased artefact removal has been widely applied in human and rodent studies (Griffanti et al, 2015Han et al, 2019;Salimi-Khorshidi et al, 2014;Smith et al, 2013). It leverages the independency between spatial and/or temporal patterns of the neural and non-neural components to separate them.…”

Section: Ica-based Artefact Identificationmentioning

confidence: 99%

An open database of resting-state fMRI in awake rats

Liu

Pérez

et al. 2019

Preprint

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Rodent models are essential to translational research in health and disease.Investigation in rodent brain function and organization at the systems level using restingstate functional magnetic resonance imaging (rsfMRI) has become increasingly popular, owing to its high spatial resolution and whole-brain coverage. Due to this rapid progress, shared rodent rsfMRI databases can be of particular interest and importance to the scientific community, as inspired by human neuroscience and psychiatric research that are substantially facilitated by open human neuroimaging datasets. However, such databases in rats are still lacking. In this paper, we share an open rsfMRI database acquired in 90 rats with a well-established awake imaging paradigm that avoids anesthesia interference. Both raw and preprocessed data are made publically available.Procedures in data preprocessing to remove artefacts induced by the scanner, head motion, non-neural physiological noise are described in details. We also showcase interregional functional connectivity and functional networks calculated from the database.

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“…The main disadvantage of these methods is their inability to associate brain activity with behaviour. Therefore, fMRI studies in awake animals are vital [44][45][46][47] . Very recently, Han et al have nicely developed a protocol to perform awake and behaving mouse fMRI during Go/No-Go task and presented a brain-wide activation pattern of both Go and No-Go tasks 47 .…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, fMRI studies in awake animals are vital [44][45][46][47] . Very recently, Han et al have nicely developed a protocol to perform awake and behaving mouse fMRI during Go/No-Go task and presented a brain-wide activation pattern of both Go and No-Go tasks 47 . Together with this innovative new protocol, our experimental system will offer promises to advance fundamental AD research and indispensable information to understand the etiology of AD.…”

Section: Discussionmentioning

confidence: 99%

Hyper BOLD Activation in Dorsal Raphe Nucleus of APP/PS1 Alzheimer’s Disease Mouse during Reward-Oriented Drinking Test under Thirsty Conditions

Sakurai

Shintani

Jomura

et al. 2020

Sci Rep

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Alzheimer's disease (AD), a neurodegenerative disease, causes behavioural abnormalities such as disinhibition, impulsivity, and hyperphagia. preclinical studies using AD model mice have investigated these phenotypes by measuring brain activity in awake, behaving mice. in this study, we monitored the behavioural alterations of impulsivity and hyperphagia in middle-aged AD model mice. As a behavioural readout, we trained the mice to accept a water-reward under thirsty conditions. to analyse brain activity, we developed a measure for licking behaviour combined with visualisation of whole brain activity using awake fMRI. In a water-reward learning task, the AD model mice showed significant hyperactivity of the dorsal raphe nucleus in thirsty conditions. in summary, we successfully visualised altered brain activity in AD model mice during reward-oriented behaviour for the first time using awake fMRi. this may help in understanding the causes of behavioural alterations in AD patients.Fifty million people worldwide currently suffer from dementia. This number is estimated to reach 130 million by 2050. Alzheimer's disease (AD) is a neurodegenerative disease accounting for 60-70% of dementia cases 1 . AD develops through amnestic mild cognitive impairment (MCI), in which a decrease of memory function is the only symptom can be recognised. Once dementia develops, memory and various cognitive functions decrease, behavioural and psychological symptoms of dementia (BPSP) are also exhibited 1-3 . As these symptoms progress, it becomes impossible to maintain an independent daily life. Dementia patients mostly need medical care due to BPSP rather than reducing of memory and cognitive functions. BPSP includes depression, anxiety, and apathy. Although research on these BPSP symptoms has progressed, however, most symptoms such as disinhibition, impulsivity and hyperphagia have not been analysed in the way of pathology.AD significantly impairs reward-based behaviour (by 15-20%) in patients. A typical example is hyperphagia, which stems from a lack of satiety control, similar to disorders of impulsivity and compulsivity 4,5 . The Urgency, lack of Perseverance, lack of Premeditation, Sensation Seeking (UPPS) Scale or Barrat's Impulsiveness Scale (BIS) are now used to test for impulsivity in AD patients 3 . Overeating and impulsivity have also recently been reported in AD model mice 6,7 . These observations suggest that AD mice models may be useful in studying hyperphagia and early changes in impulsive behaviour. It has also been suggested that the brainstem serotonergic system, including the dorsal raphe nucleus 8,9 and ventral temporal lobe (hippocampus, parahippocampus, amygdala), are involved in such alterations. However, the neurological mechanisms behind these phenotypes have not yet been identified. In order to elucidate these mechanistic underpinnings, direct evaluation of brain activity associated with abnormal behaviour phenotypes is required 10 .Functional magnetic resonance imaging (fMRI) is widely used in neuroscience resea...

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Awake and behaving mouse fMRI during Go/No-Go task

Cited by 78 publications

References 65 publications

Full activation pattern mapping by simultaneous deep brain stimulation and fMRI with graphene fiber electrodes

Full activation pattern mapping by simultaneous deep brain stimulation and fMRI with graphene fiber electrodes

An open database of resting-state fMRI in awake rats

Hyper BOLD Activation in Dorsal Raphe Nucleus of APP/PS1 Alzheimer’s Disease Mouse during Reward-Oriented Drinking Test under Thirsty Conditions

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