Awakening of the sleeping giant: Obesity and stroke in China

Kurth, Tobias; Leitzmann, Michael F.

doi:10.1002/ana.21973

Cited by 7 publications

(5 citation statements)

References 15 publications

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“…Ischemic stroke, the main kind of stroke, is an age‐related [20–22] and gene‐related [23,24] disease and always followed by long‐term hypertension and other cardiovascular diseases such as carotid plaque [25–27], intracranial atherosclerotic lesions, [28,29] and arterial fibrillation [30–32]. Moreover, hyperlipemia, diabetes, smoke, alcohol abuse, obesity, salt intake, and many other factors also contribute to the pathogenesis of stroke [1,3,4,20,23,33–38]. After the occlusion of blood supply, severe hypoxia and activation of many toxic metabolites, such as reactive oxygen species, excitatory amino acid and excessive calcium ion, could trigger more deteriorative signal cascades and further damage the brain tissue around the lesions.…”

Section: Discussionmentioning

confidence: 99%

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Deficiency of NG2⁺ Cells Contributes to the Susceptibility of Stroke‐Prone Spontaneously Hypertensive Rats

Wang

Tian

Song

et al. 2011

CNS Neuroscience & Therapeutics

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Section: Discussionmentioning

confidence: 99%

“…Stroke is a leading cause of morbidity and mortality worldwide [1], including China [2–4]. Many efforts for developing effective therapeutic strategies have been made for a long time, whereas the perspective of stoke treatment remains a critical challenge.…”

Section: Introductionmentioning

confidence: 99%

Deficiency of NG2⁺ Cells Contributes to the Susceptibility of Stroke‐Prone Spontaneously Hypertensive Rats

Wang

Tian

Song

et al. 2011

CNS Neuroscience & Therapeutics

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“…We hypothesized that the effective increase in abdominal fat accumulation, represented by the increase in abdominal circumference regardless of the increase in body mass, might disturb lipid and TherapeuTic advances in neurological disorders Volume 16 10 journals.sagepub.com/home/tan glucose metabolism and resulted in adverse effects. 28,29 In addition, we revealed a significant association between the occurrence of END and higher neutrophil and lower lymphocyte counts. 30 A study in South Korea evaluated 438 patients with single subcortical infarctions and showed that the neutrophil-to-lymphocyte ratio (NLR) was positively associated with END.…”

Section: Discussionmentioning

confidence: 55%

Early neurological deterioration in patients with acute ischemic stroke: a prospective multicenter cohort study

Liu

Zhang

et al. 2023

Ther Adv Neurol Disord

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Background: There is still no precise knowledge of the causes of progression in patients with acute ischemic stroke (AIS), and we are unable to predict patients at risk. Objective: To explore the frequency, predictive factors, and the prognosis of early neurological deterioration (END) in patients with AIS Methods: In this prospective multicenter observational study, we assessed patients with AIS admitted to 18 hospitals in Henan, China. We defined END as an increase of ⩾2 points in total National Institutes of Health Stroke Scale (NIHSS) score or ⩾1 point in the motor items of the NIHSS within 7 days after admission. Risk factors were analyzed using multivariate logistic regression models. Prognosis was evaluated using the modified Rankin Scale (mRS), with poor prognosis defined as mRS 3–6. Results: A total of 9114 patients with AIS within 24 h of symptom onset were enrolled in the study. END occurred in 1286 (14.1%) patients. The highest incidence (62.5%) of END occurred within 24 h after admission. After adjusting potential confounders, age, body mass index, waist–hip ratio, systolic blood pressure, baseline NIHSS, disabled at baseline, history of atrial fibrillation, diabetes mellitus, intracranial arterial stenosis, infarct location in the lenticulostriate artery area and cerebral watershed, neutrophils, lymphocytes, uric acid, and triglycerides were identified as independent predictors for END. END was significantly associated with poor prognosis at 90 days, and the adjusted OR was 1.74 (95% CI: 1.53–1.97). Conclusion: One in seven hospitalized patients with AIS may experience END within 24 h of onset. The highest incidence of END occurred within 24 h of admission and decreased steeply with time. Easily identifiable risk factors predict END and could help understand the causal mechanisms and thereby prevent END.

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“…Recent large studies of initially healthy individuals demonstrate that adiposity increased the risk of vascular events 55–61 . In particular, abdominal adiposity is strongly and positively associated with CVD mortality independent of BMI 62–64 . Although obesity and hypercholesterolaemia were thought for many years to be the predominant pathogenic factors for atherosclerosis, 65 it is now evident that inflammation plays a major part in disease progression 18 …”

Section: Adipokines Inflammation and Cardiovascular Diseasementioning

confidence: 99%

Adipokines in inflammation, insulin resistance and cardiovascular disease

Wang

Miao

2011

Clin Exp Pharma Physio

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1. Obesity is a major determinant of cardiovascular disease (CVD). Studies in the past two decades have shown that adipose tissue is not merely an inert energy reserve of triglycerides, but also an active endocrine organ. 2. Adipose tissue can produce and secrete numerous bioactive peptides and/or proteins termed adipokines. These secretory factors are involved in the regulation of local and systemic inflammation and insulin sensitivity in a paracrine and/or endocrine manner. Inflammation and insulin resistance (IR) play critical roles in the obesity-linked development of CVD, such as atherosclerosis, hypertension and restenosis. 3. In the present minireview, we summarize the relationship between inflammation and IR, as well as their contribution to the development of CVD during adipose tissue dysfunction. In particular, we focus on the effects of various adipokines in pathological processes, which may provide an insight into obesity-linked CVD and facilitate the development of new therapeutic strategies.

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Awakening of the sleeping giant: Obesity and stroke in China

Cited by 7 publications

References 15 publications

Deficiency of NG2⁺ Cells Contributes to the Susceptibility of Stroke‐Prone Spontaneously Hypertensive Rats

Deficiency of NG2⁺ Cells Contributes to the Susceptibility of Stroke‐Prone Spontaneously Hypertensive Rats

Early neurological deterioration in patients with acute ischemic stroke: a prospective multicenter cohort study

Adipokines in inflammation, insulin resistance and cardiovascular disease

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Awakening of the sleeping giant: Obesity and stroke in China

Cited by 7 publications

References 15 publications

Deficiency of NG2+ Cells Contributes to the Susceptibility of Stroke‐Prone Spontaneously Hypertensive Rats

Deficiency of NG2+ Cells Contributes to the Susceptibility of Stroke‐Prone Spontaneously Hypertensive Rats

Early neurological deterioration in patients with acute ischemic stroke: a prospective multicenter cohort study

Adipokines in inflammation, insulin resistance and cardiovascular disease

Contact Info

Product

Resources

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Deficiency of NG2⁺ Cells Contributes to the Susceptibility of Stroke‐Prone Spontaneously Hypertensive Rats

Deficiency of NG2⁺ Cells Contributes to the Susceptibility of Stroke‐Prone Spontaneously Hypertensive Rats