Awareness and perception of pharmacy researchers about conflict of interest: A study from the MENA region

Mashaqhbeh, Hadeia; Alzoubi, Karem H.; Khabour, Omar F.; Farha, Rana Abu

doi:10.7324/japs.2022.120815

Cited by 3 publications

(1 citation statement)

References 56 publications

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“…Graptophyllum pictum (L.) Griff ( G. pictum ), also known as “wungu leaves” or “purple leaves,” is a shrub plant native to Indonesia and is found in several countries. [ 1 ] G. pictum is widely used in traditional medicine due to its antioxidant,[ 2 ] anti-hemorrhoid,[ 3 ] anti-inflammatory,[ 4 ] and analgesic[ 5 ] bioactivity. G. pictum contains various active compounds, including flavonoids, tannins, alkaloids, steroids, and saponins.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant potential and polyphenol content in different parts of Graptophyllum pictum extracts

Makkiyah,

Rahmi,

Arista

et al. 2024

Journal of Advanced Pharmaceutical Technology &Amp; Research

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The antioxidant potential of Graptophyllum pictum (wungu leaves), an indigenous shrub plant extensively used in traditional medicine in Indonesia, was investigated in this study. The research focused on a comprehensive evaluation of total phenolic content (TPC), total flavonoid content (TFC), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and ferric-reducing antioxidant power (FRAP) across various plant parts, including roots, stems, and flowers, which had been underexplored in prior studies. The ethanol extract derived from wungu flowers and leaves demonstrated notable antioxidant potential, characterized by elevated TPC (12.22 ± 0.31 mg GAE/g DW) and FRAP (37.73 ± 1.08 μmol TEAC/g DW) in the ethanol extract of wungu flowers. Similarly, the ethanol extract of wungu leaves showcased a substantial TFC (2.31 ± 0.18 mg QE/g DW) and DPPH (1.12 ± 0.05 μmol TEAC/g DW), surpassing other parts of the wungu plant in the same or different extracts. These findings suggested that ethanol extracts were a promising foundation for herbal medicines with antioxidant properties, highlighting their potential applications in plant breeding programs. Furthermore, the correlation data underscored the significance of the ethyl acetate and ethanol extracts, revealing a robust correlation between TPC, TFC, and FRAP compared to the n-hexane extract.

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Section: Introductionmentioning

confidence: 99%

Antioxidant potential and polyphenol content in different parts of Graptophyllum pictum extracts

Makkiyah,

Rahmi,

Arista

et al. 2024

Journal of Advanced Pharmaceutical Technology &Amp; Research

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Evaluation of Awareness and Perception Regarding Conflict of Interest in Research Among the Postgraduate Students in a Tertiary Care Center

Ghajbhiye,

Tripathi,

Jalgoankar

et al. 2024

Journal of Pharmacology and Pharmacotherapeutics

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Background and Purpose Conflict of interest (COI) exists when a set of circumstances creates a risk that a secondary interest will unduly influence professional judgment or actions regarding a primary interest. This knowledge regarding ethics and rights is given to postgraduate students in their first year of residency through various training programs. In this training, one of the concepts taught is COI. There is no available literature regarding awareness of COI among postgraduate students who are going to be future researchers; hence we decided to conduct this study. Materials and Methods It was a cross-sectional, observational, single-center, questionnaire-based Study. The validated questionnaire was administered to the postgraduate students after obtaining their written informed consent. These questions were designed based on four domains: Awareness, perception, case scenarios, and application of COI. The responses were recorded as yes/no & presented in descriptive statistics. Results The mean age of the participants was 28.67 years with a standard deviation (SD) of 1.92. Sixty-one percent of were female. More than 85% of postgraduate residents have an awareness of COI. Also, 70% of participants felt that increased protocol deviations and 91% reported research study outcomes are likely to be positive when there is COI in the study. Ninety-three percent of participants thought that education regarding COI was necessary. Conclusion The majority of postgraduate students had an awareness of COI. Postgraduate students perceived that the results of the study involving COI may not be credible, and formal education and training are required in this area.

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Anthocyanin-Containing Purple Sweet Potato (Ipomoea batatas L.) Synbiotic Yogurt Inhibited 3T3-L1 Adipogenesis by Suppressing White Adipocyte-Specific Genes

Ariyanto,

Shalannandia,

Lantika

et al. 2023

JEP

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We unravel the effect of anthocyanin-containing purple sweet potato synbiotic yogurt (PSPY) on 3T3-L1 adipocyte differentiation and its fundamental molecular mechanisms. Methods: Molecular docking simulation was performed to observe and identify the affinity and interaction between bioactive compounds and targeted proteins. MDI (isobutylmethylxanthine, dexamethasone, and insulin)-containing medium, a cocktail that stimulates adipogenesis, was used in this study. The toxic effect possibility of the yogurt product was evaluated using 3-[4, 5-dimethylthiazol-2-yl]-2.5 diphenyl tetrazolium bromide (MTT) assay. A 0.25%, 0.5%, 1%, and 5% (v/v) plain or purple sweet potato yogurt supernatant was given to 3T3-L1 preadipocyte culture medium from 24 h after seeding until day 11 of MDI-induced differentiation. The mRNA expression and lipid accumulation were analyzed using RT-qPCR and Oil red O staining, respectively, on day 11 after differentiation induction. Results: In silico study suggested that anthocyanin-derived compounds have the potential to inhibit peroxisome proliferator activated receptor gamma (PPAR-γ), a master regulator for white adipogenesis. Anthocyanin-containing PSPY significantly suppressed the expression of Pparg, Adipoq, Slc2a4, and Pgc1a. PSPY significantly suppressed Pparg with 1% and 5% concentrations, while with a concentration of 0.25%, PSPY significantly suppressed Adipoq expression as compared to control. Significant inhibition of Slc2a4 and Pgc1a was observed starting from a 0.25% concentration of PSPY. The suppression of adipogenic genes was also observed with the treatment of plain yogurt; however, the effects were relatively lower than the PSPY. The group treated with 1% and 5% of PSPY also showed inhibition effects on lipid accumulation. Conclusion: This study demonstrated PSPY inhibition effect on white adipocyte differentiation through suppression of Pparg and its downstream genes, Adipoq and Slc2a4, indicating the potential of this yogurt as a functional food for obesity management and prevention.

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Awareness and perception of pharmacy researchers about conflict of interest: A study from the MENA region

Cited by 3 publications

References 56 publications

Antioxidant potential and polyphenol content in different parts of Graptophyllum pictum extracts

Antioxidant potential and polyphenol content in different parts of Graptophyllum pictum extracts

Evaluation of Awareness and Perception Regarding Conflict of Interest in Research Among the Postgraduate Students in a Tertiary Care Center

Anthocyanin-Containing Purple Sweet Potato (Ipomoea batatas L.) Synbiotic Yogurt Inhibited 3T3-L1 Adipogenesis by Suppressing White Adipocyte-Specific Genes

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