“…The appropriate dosage of ultraviolet radiation (UVR) from sunlight not only enhances blood circulation and metabolism but also prevents and cures rickets . However, prolonged exposure to ultraviolet (UV) rays can lead to various health problems, such as sunburns, photodermatoses, photoaging, and even skin cancers. − To reduce these negative effects, sunscreens have been extensively used to protect the skin from UV rays. Inorganic UV filters, such as titanium dioxide (TiO 2 ) and zinc oxide nanoparticles, can reflect and scatter UV rays and are generally regarded as non-skin penetration. , However, they have a considerable photocatalytic generation of reactive oxygen species (ROS) , and pose a threat to cellular macromolecules such as proteins, lipids, DNA, and membranes, − causing inflammatory responses, and eventually carcinogenesis. , To eliminate the photoinduced ROS, several strategies such as coating, ion doping, or encapsulation have been adopted to overcome these challenges. , However, some improvements are not always satisfactory and often bring new issues that are not conducive to their application in skin care products.…”