Awareness on the possible adverse effects of Garcinia cambogia: A scientific approach

Zothantluanga, James H.; Lalnunpuii, Hannah S.; Bhat, Hans Raj; Shakya, Anshul

doi:10.33493/scivis.19.04.02

Cited by 6 publications

(4 citation statements)

References 61 publications

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“…In the present study, based on the fact that caffeine has both weight loss and arousal-inducing effects, we screened the arousal-inducing effects of five dietary supplements with proven weight loss effects ( Garcinia cambogia , Coleus forskohlii , Camellia sinensis L., Irvingia gabonensis , and Malus pumila M.) . G. cambogia is a member of the family Clusiaceae and has (−)-hydroxycitric acid (HCA), which inhibits the synthesis of fatty acids and lipogenesis [ 25 , 26 , 27 ]. C .…”

Section: Introductionmentioning

confidence: 99%

Arousal-Inducing Effect of Garcinia cambogia Peel Extract in Pentobarbital-Induced Sleep Test and Electroencephalographic Analysis

Kim

Yoon

et al. 2021

Nutrients

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Caffeine, a natural stimulant, is known to be effective for weight loss. On this basis, we screened the arousal-inducing effect of five dietary supplements with a weight loss effect (Garcinia cambogia, Coleus forskohlii, Camellia sinensis L., Irvingia gabonensis, and Malus pumila M.), of which the G. cambogia peel extract (GC) showed a significant arousal-inducing effect in the pentobarbital-induced sleep test in mice. This characteristic of GC was further evaluated by analysis of electroencephalogram and electromyogram in C57L/6N mice, and it was compared to that of the positive control, caffeine. Administration of GC (1500 mg/kg) significantly increased wakefulness and decreased non-rapid eye movement sleep, similar to that of caffeine (25 mg/kg), with GC and caffeine showing a significant increase in wakefulness at 2 and 6 h, respectively. Compared to that of caffeine, the shorter duration of efficacy of GC could be advantageous because of the lower possibility of sleep disturbance. Furthermore, the arousal-inducing effects of GC (1500 mg/kg) and caffeine (25 mg/kg) persisted throughout the chronic (3 weeks) administration study. This study, for the first time, revealed the arousal-inducing effect of GC. Our findings suggest that GC might be a promising natural stimulant with no side effects. In addition, it is preferential to take GC as a dietary supplement for weight loss during the daytime to avoid sleep disturbances owing to its arousal-inducing effect.

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Section: Introductionmentioning

confidence: 99%

Arousal-Inducing Effect of Garcinia cambogia Peel Extract in Pentobarbital-Induced Sleep Test and Electroencephalographic Analysis

Kim

Yoon

et al. 2021

Nutrients

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“…79 Other side effects include: upset stomach or diarrhoea, dizziness, headache, and dry mouth. 80,81 Another issue…”

Section: Enhancers Of Energy Expenditurementioning

confidence: 99%

“…79 Other side effects include: upset stomach or diarrhoea, dizziness, headache, and dry mouth. 80,81 Another issue observed is that Garcinia cambogia may adversely interact with medicines for diabetes, pain and psychiatric conditions. 82 So, further studies are needed to demonstrate if HCA or extracts of Garcinia cambogia administration help in weight loss.…”

Section: How To Target Energy Balancementioning

confidence: 99%

Recent advancements in pharmacological strategies to modulate energy balance for combating obesity

Pati,

Sendh,

Sahu

et al. 2023

RSC Med. Chem.

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“…47,48 Worryingly, adverse effects that are induced by natural products had been reported. 49 Thus, it is important to consider the toxicity issues that might be associated with natural products. Therefore, pre-clinical techniques may be used to generate data on the pharmacological efficacy, safety as well as toxicity of a potential drug candidate.…”

Section: Future Challengesmentioning

confidence: 99%

Ethnopharmacology and phytochemistry-based review on the antimalarial potential of Acacia pennata (L.) Willd.

Zothantluanga¹

2020

Sci Vis

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A protozoan infection called malaria is caused by Plasmodium parasites. In 2018, it infected more than 228 million people and caused 405,000 fatalities. Worryingly, the present antimalarial drugs had developed drug resistance. Furthermore, they are associated with adverse effects and price issues. Amidst the gloomy scenario, drug discovery based on natural products had renewed the hope to overcome the burdens associated with the present antimalarial drugs. Auspiciously, medicinal plants had contributed significantly to the modern pharmacotherapy of malaria. Interestingly, Acacia pennata (L.) Willd. was also documented as a traditional antimalarial agent. However, there is still no scientific evidence regarding its antimalarial activity. Therefore, this article was aimed to study the phytochemical profile of A. pennata and explore their potential activity against malarial parasites. A. pennata contains different classes of bioactive compounds such as alkaloids, flavonoids, phenols, glycosides, terpenoids, phytosterols, and saponins whose antimalarial activities had been reported. Accordingly, the future scopes and challenges regarding the possible antimalarial activity for A. pennata are also discussed. To maximize the chances for finding a new antimalarial chemical entity from A. pennata, a schematic flow chart on the ethnopharmacology based drug discovery approach is also provided. Thus, this literary work may be used by researchers as a referential guide in the search for new antimalarial phytochemicals.

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Awareness on the possible adverse effects of Garcinia cambogia: A scientific approach

Cited by 6 publications

References 61 publications

Arousal-Inducing Effect of Garcinia cambogia Peel Extract in Pentobarbital-Induced Sleep Test and Electroencephalographic Analysis

Arousal-Inducing Effect of Garcinia cambogia Peel Extract in Pentobarbital-Induced Sleep Test and Electroencephalographic Analysis

Recent advancements in pharmacological strategies to modulate energy balance for combating obesity

Ethnopharmacology and phytochemistry-based review on the antimalarial potential of Acacia pennata (L.) Willd.

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