Axial dispersion of submicron particles in capillary hydrodynamic fractionation

Silebi, C. A.; DosRamos, J. G.

doi:10.1002/aic.690350814

Cited by 21 publications

(13 citation statements)

References 50 publications

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“…(15) are given in refs. [6,41]. Figure 12 compares the radial distributions calculated from the spatial part of the Boltzmann distribution (15) (solid lines) and determined from the simulated particle trajectories (dashed lines).…”

Section: From Lift Forces To Radial Distribution Functionsmentioning

confidence: 99%

Inertial microfluidics with multi-particle collision dynamics

2012

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Abstract. Using the method of multi-particle collision dynamics (MPCD), we investigate inertial focussing in microfluidic channels that gives rise to the Segré-Silberberg effect. At intermediate Reynolds numbers, we model the motion of a spherical colloid in a circular microchannel under pressure-driven flow. We determine the radial distribution function and show how its width and the location of its maximum are strongly influenced by the colloid size and the Reynolds number of the Poiseuille flow. We demonstrate that MPCD is well suited for calculating mean values for the lift force acting on the colloid in the crosssectional plane and for its mean axial velocity. We introduce a Langevin equation for the cross-sectional motion whose steady state is the Boltzmann distribution that contains the integrated lift force as potential energy. It perfectly coincides with the simulated radial distribution function.

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Section: From Lift Forces To Radial Distribution Functionsmentioning

confidence: 99%

Inertial microfluidics with multi-particle collision dynamics

2012

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“…In this invention [52] the fused silica open capillaries had internal diameters located in the range 4 -60 μm and lengths 1 -50 m.…”

Section: Latexesmentioning

confidence: 99%

“…PCHDC and CHDC (also known by capillary hydrodynamic fractionation [52][53][54]) had an important role in the referred revitalization [55]. PCHDC was invented in the laboratories from Dow Chemical Company [51] and it took ten years to be transferred from a laboratory method into a commercial instrument.…”

Section: Latexesmentioning

confidence: 99%

“…In CHDC there is much less propensity for the particles to deposit in the open capillary. The commercial embodiment of CHDC has become available from Matec Applied Sciences after the works from Silebi and Dos Ramos [52][53][54], this instrument being widely used nowadays [56][57][58][59][60][61][62].…”

Section: Latexesmentioning

confidence: 99%

“…HDC can be used in the size fractionation of organic and water soluble synthetic polymers [4-13, 52, 92, 93] or biopolymers [5,9,11,[17][18][19][20]52]. Prud´homme et al [93] developed a method for characterizing the molecular weight and molecular weight distribution of ultra-high molecular weight water soluble polymers (polyacrylamide, poly-acrylamide/acrylic acid copolymers, etc.).…”

Section: Synthetic Polymers and Biopolymersmentioning

confidence: 99%

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Size Fractionation by Slalom Chromatography and Hydrodynamic Chromatography

Dias¹

2008

ENG

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Hydrodynamic chromatography, also called separation by flow, is based on the use of the parabolic flow profile occurring in open capillaries or in the pores from a column filled with non-porous particles. The hydrodynamic chromatography separation medium, if any, is much simpler than that from size exclusion chromatography (porous particles), the former technique being used in the size-fractionation of many colloids and macromolecules. The transition between hydrodynamic chromatography (obtained using low flow rates) and slalom chromatography (obtained using high flow rates) was reported in studies related with the migration behaviour of proteins, plasmid DNAs and double stranded DNAs. Slalom chromatography is mainly applied in the size-fractionation of large double stranded DNA fragments and may compete with electrophoretic techniques. In the present paper it is discussed the main patents, applications, advantages and drawbacks related to hydrodynamic chromatography and slalom chromatography, as well as some strategies that may improve the performance of these simple size-fractionation techniques.

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Electrokinetic dispersion in capillary electrophoresis

Datta

Kotamarthi

1990

AIChE Journal

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A "Taylor" dispersion-type model is developed for the electrokinetic dispersion coefficient of a solute in capillary electrophoresis that accounts for the effects of Poiseuille andlor electro-osmotic flow of the elutant for the case of low potential. The expression obtained for the height equivalent of a theoretical plate is compared with experimental results reported in the literature for the case of neutral, nonretained solutes propelled by electro-osmotic flow. The results further reveal some interesting and somewhat unexpected interactions of the electroosmotic and Poiseuille components of the elutant flow. Superposition of Poiseuille flow on the natural electro-osmotic flow allows greater freedom in the choice of elutant velocity, without necessarily increasing the dispersion. In fact, it results in lower dispersion under some conditions. Optimum flow conditions are obtained for minimizing the plate height or, equivalently, for maximizing the Peclet number.

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Axial dispersion of submicron particles in capillary hydrodynamic fractionation

Cited by 21 publications

References 50 publications

Inertial microfluidics with multi-particle collision dynamics

Inertial microfluidics with multi-particle collision dynamics

Size Fractionation by Slalom Chromatography and Hydrodynamic Chromatography

Electrokinetic dispersion in capillary electrophoresis

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