Axial Multicentric Osteosarcoma in an English Cocker Spaniel

Parzefall, Birgit; Decker, Steven De; Carvalho, S.; Terry, Rebecca; Leach, Joshua; Smith, Ken; Lara-García, Ana

doi:10.1111/jvim.14555

Cited by 2 publications

(4 citation statements)

References 30 publications

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“…The toceranib was replaced by carboplatin after 4 months due to progression of the lesions and again 5 months later to chlorambucil. In this report, the dog survived for 15 months after diagnosis 13…”

Section: Discussionmentioning

confidence: 77%

“…In one case report of an axial multicentric osteosarcoma in an English Cocker Spaniel by Parzefall et al, 13 the dog underwent symptomatic analgesic treatment, hypofractioned radiotherapy, tramadol, paracetamol‐codeine and firocoxib, bisphosphonates such as pamidronate and toceranib phosphate. The toceranib was replaced by carboplatin after 4 months due to progression of the lesions and again 5 months later to chlorambucil.…”

Section: Discussionmentioning

confidence: 99%

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Osteosarcoma affecting multiple bones in a dog

Wyatt¹,

Piviani²,

Rich³

et al. 2019

Vet Record Case Reports

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A 9 years and 5 months old, neutered male, Rottweiler was presented for referral at the Small Animal Teaching Hospital, University of Liverpool, for investigations following a fracture of the left femur, which had occurred after minor trauma. Radiographs at the primary veterinary practice revealed a closed, slightly displaced, comminuted, proximal diaphyseal fracture, which had cortical thinning around the fracture site, suggestive of a pathological fracture. Advanced imaging (computed tomography) revealed polyostotic osteolytic lesions which contained contrast enhancing, soft tissue attenuating tissue, associated with cortical destruction throughout the appendicular and axial skeleton. Ultrasound-guided fine needle aspirates of four lesions (right scapular, right femoral, left pelvic and vertebral lesions) were assessed by a boarded clinical pathologist, confirmed diagnosis of a polyostotic osteosarcoma. The patient was euthanased and postmortem examination confirmed the diagnosis.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Osteosarcoma affecting multiple bones in a dog

Wyatt¹,

Piviani²,

Rich³

et al. 2019

Vet Record Case Reports

View full text Add to dashboard Cite

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“…Multiple osteolytic lesions with associated periosteal new bone formation have been described due to metastasis to the vertebrae, sacrum pelvis, femur, scapula and humerus in dogs with urothelial carcinoma 9. Lytic lesions involving multiple bony structures have been recognised in the literature with other forms of neoplasia, such as multicentric osteosarcoma, multiple myeloma and lymphoma 22. Multiple mineral nodules of varied sizes within the medullary cavity of long bones, sternum and pelvis has been described as bone marrow metastasis by an insulin‐secreting beta‐cell carcinoma in a dog 21…”

Section: Discussionmentioning

confidence: 99%

“…9 Lytic lesions involving multiple bony structures have been recognised in the literature with other forms of neoplasia, such as multicentric osteosarcoma, multiple myeloma and lymphoma. 22 Multiple mineral nodules of varied sizes within the medullary cavity of long bones, sternum and pelvis has been described as bone marrow metastasis by an insulin-secreting beta-cell carcinoma in a dog. 21 In conclusion, this the first case documenting presumptive manifestation of disseminated carcinomatosis of the bone marrow of an MCUP origin.…”

Section: Discussionmentioning

confidence: 99%

Presumed disseminated carcinomatosis of the bone marrow in a dog

Gomes

Gunn

Millins

et al. 2020

Vet Record Case Reports

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An eight-year-old male neutered Jack Russell terrier presented with fever, shoulder and elbow pain and progressive right forelimb lameness. Haematology revealed a non-regenerative anaemia and marked thrombocytopenia. Radiography and CT of the thorax and abdomen revealed bilateral asymmetrical osteogenic-osteolytic changes to the scapulae, humeri, femurs, pelvis, ribs and vertebrae. Histopathology of the bone marrow of the left humerus confirmed a metastatic skeletal adenocarcinoma. This case features a presumptive manifestation of disseminated carcinomatosis of the bone marrow with a bilateral asymmetrical distribution in a metastatic adenocarcinoma of unknown primary origin. Disseminated carcinomatosis of the bone marrow should be included in the differential diagnosis with polyostotic osteolytic and osteogenic, bilateral asymmetrical lesions in the long bones, vertebrae, ribs and pelvis.

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Axial Multicentric Osteosarcoma in an English Cocker Spaniel

Cited by 2 publications

References 30 publications

Osteosarcoma affecting multiple bones in a dog

Osteosarcoma affecting multiple bones in a dog

Presumed disseminated carcinomatosis of the bone marrow in a dog

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