Axial Signal Analysis and Image Reconstruction in Acoustic Lens Photoacoustic Imaging System

Yu, Zhang; Tang, Zhilie; Wu, Yongbo; Zhang, F. D. Jiantong

doi:10.1109/access.2016.2619359

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…So, PAI can provide a high lateral resolution for the structural and functional imaging of samples. [1][2][3][4][5][6][7][8][9] Photoacoustic imaging technique has characteristics of deep acoustic penetration depth and high optical contrast. It can be used to image multiscale samples.…”

Section: Introductionmentioning

confidence: 99%

The Dual-Mode Imaging of Nanogold-Labeled Cells by Photoacoustic Microscopy and Fluorescence Optical Microscopy

Tang

Xue

et al. 2018

Technol Cancer Res Treat

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Photoacoustic microscopy is dominantly sensitive to the endogenous optical absorption, while a fluorescence optical microscopy can detect the fluorescence emission to obtain the image of a sample. To some extent, the physical processes of the 2 methods are opposite, one is absorption and another is emission, but both can be used to image cells. In this article, a simultaneous dual-mode imaging system of photoacoustic microscopy and fluorescence optical microscopy is set up to image tobacco cells. Furthermore, gold nanoparticles, which have a large absorption coefficient and enough fluorescence emission with wavelength of 512 nm, are used to label certain drugs and added to the tobacco cells. Then based on the simultaneous dual-mode microscopy imaging system, the photoacoustic microscopy and fluorescence optical microscopy images of gold nanoparticle-labeled tobacco cells are obtained. The final purpose of this experimental research is to detect if the labeled drugs can enter the cells by the positions of the gold nanoparticles. This will help the experts to deliver organic pesticide more accurately and effectively. The experimental results show that by gold nanoparticle labeling technology, the imaging quality of photoacoustic microscopy and fluorescence optical microscopy can be improved, which indicates that the drugs probably enter the tobacco cells successfully.

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Section: Introductionmentioning

confidence: 99%

The Dual-Mode Imaging of Nanogold-Labeled Cells by Photoacoustic Microscopy and Fluorescence Optical Microscopy

Tang

Xue

et al. 2018

Technol Cancer Res Treat

Self Cite

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Biomedical instrumentation of photoacoustic imaging and quantitative sensing for clinical applications

Khan,

Vasudevan

2023

Review of Scientific Instruments

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Photoacoustic (PA) imaging has been well researched over the last couple of decades and has found many applications in biomedical engineering. This has evinced interest among many scientists in developing this as a compact instrument for biomedical diagnosis. This review discusses various instrumentation developments for PA experimental setups and their applications in the biomedical diagnostic field. It also covers the PA spectral response or PA sensing technique, which uses the spectral information of the PA signal and performs sensing to deliver a fast, cost-effective, and compact screening tool instead of imaging. Primarily, this review provides an overview of PA imaging concepts and the development of hardware instrumentation systems in both the excitation and acquisition stages of this technique. Later, the paper discusses PA sensing, the quantitative spectral parameter extraction from the PA spectrum, and the correlation study of the spectral parameters with the physical parameters of the tissue. This PA sensing technique was used to diagnose various diseases, such as thyroid nodules, breast cancer, renal disorders, and zoonotic diseases, based on the mechanical and biological characteristics of the tissues. The paper culminates with a discussion section that provides future developments that are necessary to take this technique into clinical applications as a quantitative PA imaging technique.

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Axial Signal Analysis and Image Reconstruction in Acoustic Lens Photoacoustic Imaging System

Cited by 2 publications

References 15 publications

The Dual-Mode Imaging of Nanogold-Labeled Cells by Photoacoustic Microscopy and Fluorescence Optical Microscopy

The Dual-Mode Imaging of Nanogold-Labeled Cells by Photoacoustic Microscopy and Fluorescence Optical Microscopy

Biomedical instrumentation of photoacoustic imaging and quantitative sensing for clinical applications

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