Axial strain imaging of intravascular data: results on polyvinyl alcohol cryogel phantoms and carotid artery

Brusseau, E.; Fromageau, J.; Finet, Gérard; Delachartre, Philippe; Vray, Didier

doi:10.1016/s0301-5629(01)00451-3

Cited by 67 publications

(45 citation statements)

References 26 publications

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“…[1][2][3][4] Changes in the mechanical properties of tissues are known to correlate closely with various pathological conditions and hence ultrasound elastography should provide a method for differentiating between various abnormalities and pathological states which may not be apparent using traditional ultrasound imaging techniques. [5][6][7] The technology has now reached the stage where numerous incarnations have left the research laboratory and are appearing in the clinical environment.…”

Section: Introductionmentioning

confidence: 99%

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Review of ultrasound elastography quality control and training test phantoms

Cournane

Fagan

Browne³

2011

Ultrasound

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While the rapid development of ultrasound elastography techniques in recent decades has sparked its prompt implementation in the clinical setting adding new diagnostic information to conventional imaging techniques, questions still remain as to its full potential and efficacy in the hospital environment. A limited number of technical studies have objectively assessed the full capabilities of the different elastography approaches, perhaps due, in part, to the scarcity of suitable tissue-mimicking materials (TMMs) and appropriately designed phantoms available. Few commercially available elastography phantoms possess the necessary test target characteristics or mechanical properties observed clinically, or indeed reflect the lesion-to-background elasticity ratio encountered during clinical scanning. Thus, while some phantoms may prove useful, they may not fully challenge the capabilities of the different elastography techniques, proving limited when it comes to quality control (QC) and/or training purposes. Although a variety of elastography TMMs, such as agar and gelatine dispersions, co-polymer in oil and poly(vinyl) alcohol cryogel, have been developed for specific research purposes, such work is yet to produce appropriately designed phantoms to adequately challenge the variety of current commercially available elastography applications. Accordingly, there is a clear need for the further development of elastography TMMs and phantoms to keep pace with the rapid developments in elastography technology, to ensure that the performance of these new diagnostic approaches are validated, and for clinical training purposes.

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Section: Introductionmentioning

confidence: 99%

“…[5][6][7] Test objects are widely used in ultrasound imaging. These reproduce the essential geometric features of tissue and are acoustically equivalent so that images are comparable with those produced clinically.…”

Section: Introductionmentioning

confidence: 99%

Review of ultrasound elastography quality control and training test phantoms

Cournane

Fagan

Browne³

2011

Ultrasound

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“…Tissue mimicking materials currently being researched for use as elastography phantoms include: oil-in-agar, oil-in-gelatin and agar dispersions (Madsen et al, 2005); co-polymer in oil (Oudry et al, 2009); polyacrylamide gels (Klinkosz et al, 2008;Luo and Konofagou, 2009); and a relatively novel approach using poly(vinyl alcohol) cryogel (Brusseau et al, 2001;Fromageau et al, 2007;Chu and Rutt, 1997;Surry et al, 2004). Oil-in-agar, oil-in-gelatin and agar dispersions can achieve Young's modulus values ranging from 5 -135 kPa, which is representative of soft tissue (de Korte et al, 1997;Madsen et al, 2005Madsen et al, , 2006.…”

Section: Introductionmentioning

confidence: 99%

“…The stiffness properties of poly(vinyl alcohol) cryogel (PVA-C) can be manipulated by processing the material through a number of freeze/thaw cycles, varying the PVA concentration and also by controlling the rate of thawing (Chu and Rutt, 1997;Brusseau et al, 2001;Surry et al, 2004;Pazos et al, 2009). The versatility of PVA-C as a TMM phantom across ultrasound and MR modalities has been well documented (Surry et al, 2004), while its robustness and strength has been identified in work where the material has been successfully used as an aortic vessel phantom (Chu and Rutt, 1997).…”

Section: Introductionmentioning

confidence: 99%

“…It has been found that the mechanical properties of tissue correlate with its pathological condition and hence the study of properties such as the Young's modulus can provide a method for differentiating between different pathological states in tissue (Yeh et al, 2002;Sandrin et al, 2002;Brusseau et al, 2001). While palpation remains the most commonly used technique in a clinical setting for assessing tissue stiffness, whereby regions of increased stiffness serve as an indicator of diseased tissue, the need for a more sensitive, more penetrating, non-invasive and quantitative means of measuring tissue stiffness has drawn significant attention to the rapidly developing area of elastography (Park and Maniatty, 2006;Sandrin et al, 2003;Yamakoshi et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

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Assessment of the accuracy of an ultrasound elastography liver scanning system using a PVA-cryogel phantom with optimal acoustic and mechanical properties

Cournane¹,

Cannon²,

Browne³

et al. 2010

Phys. Med. Biol.

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The accuracy of a transient elastography liver-scanning ultrasound system was assessed using a novel application of PVA-cryogel as a tissue-mimicking material with acoustic and shear elasticity properties optimized to best represent those of liver tissue. Although the liver-scanning system has been shown to offer a safer alternative for diagnosing liver cirrhosis through stiffness measurement, as compared to the liver needle biopsy exam, the scanner's accuracy has not been fully established. The Young's elastic modulus values of 5-6wt% PVA-cryogel phantoms, also containing glycerol and 0.3μm Al 2 O 3 and 3μm Al 2 O 3 , were measured using a 'gold standard' mechanical testing technique and transient elastography. The mechanically measured values and acoustic velocities of the phantoms ranged between 1.6-16.1kPa and 1540-1570m/s, respectively, mimicking those observed in liver tissue. The values reported by the transient elastography system overestimated the Young's elastic modulus values representative of the progressive stages of liver fibrosis by up to 32%. These results were attributed to the relative rather than absolute nature of the measurement arising from the singlepoint acoustic velocity calibration of the system, rendering the measurements critically dependent on the speed of sound of the sample under investigation. Given the wide range of acoustic velocities which exist in the liver, spanning healthy tissue to cirrhotic pathology, coupled with the system's assumption that the liver is approximately elastic when it is rather highly viscoelastic, care should be exercised when interpreting the results from this system in patient groups.2

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Ultrasonic Elastography

Souchon¹

Physics for Medical Imaging Applications

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Abstract. Elastography is a new ultrasound-based imaging technique that provides images (called elastograms) of internal strain in soft tissues under a static compression. The strain is related to the stiffness of the tissues, which is in turn related to the pathological state of tissues. For example, it has been known for long that breast and prostate cancer are stiffer than normal tissues, and palpation is a standard medical practice. Elastography is able to provide new quantitative information about the stiffness of the tissues that would not be obtainable with existing imaging modalities. Elastograms are created by digitizing ultrasonic signals before and after applying a small static compression (usually about 1%) to the tissues being scanned. For small compressions, the displacement and the compression of the tissues induce a displacement and a temporal compression of the ultrasonic signal. These displacements are tracked by locating the position of the maximum of the cross-correlation function between the pre-and displacements, and a strain image is formed. Applications include breast, prostate, kidney and intravascular elastography, as well as thermal therapy follow-up. Although elastography is still only used in research today, it is expected that this imaging modality may become available for standard practice within a few years.

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Axial strain imaging of intravascular data: results on polyvinyl alcohol cryogel phantoms and carotid artery

Cited by 67 publications

References 26 publications

Review of ultrasound elastography quality control and training test phantoms

Review of ultrasound elastography quality control and training test phantoms

Assessment of the accuracy of an ultrasound elastography liver scanning system using a PVA-cryogel phantom with optimal acoustic and mechanical properties

Ultrasonic Elastography

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