Axillary basal cell carcinoma: additional 25 patients and considerations

Abstract

Axillary Basal cell carcinomas are rare. No particular predisposing or risk factor is recorded. They do not seem to be significantly more aggressive than other basal cell carcinomas.

Basal cell carcinoma on the bilateral axillae: a report of axillary onset basal cell carcinoma from a single institute in Japan

“…Previous studies have shown that the incidence rate of axillary BCC varies between 0.15% and 0.43% of total BCCs . In contrast, this rate in the present study was revealed to be 1.8%.…”

“…Those differences may be relevant to the lifestyle, job (outdoors or in‐house), climate, and recreational habits (sports, leisure, tanning), as well as skin types. In a previous series of 25 cases of axillary BCC, the ratio of males to females was 3 : 2 . In contrast, our cases were all females.…”

“…Unusual sites include the axillae, breasts, perianal area, genitalia, palms, and soles . To date, there have been several reports of axillary onset BCC . We reviewed six cases of axillary BCC in Japanese individuals who were treated in our university hospital including one rare case of BCC involving the bilateral axillae.…”

Basal Cell Carcinoma of the Umbilicus: A Comprehensive Literature Review

“…Strickland and colleagues postulated that ultraviolet radiation at distant sun-exposed sites may lead to a suppression of immune surveillance that in turn allows BCCs to develop in sun-protected sites [ 39 ]. Many have endorsed this theory as contributing to the formation of BCCs in other covered sites, such as the genital regions [ 40 ] and the axilla [ 25 - 26 , 41 ]. Other researchers have suggested that local alterations in cell matrix interactions lead to changes in skin texture, shape, and tension that may contribute to tumor formation in sun-protected areas [ 42 ].…”

Estudo do macrófago no carcinoma basocelular sólido recidivado após Cirurgia Micrográfica de Mohs

“…O principal fator de risco associado ao desenvolvimento do CBC é a exposição à radiação ultravioleta. Outras circunstâncias envolvidas com a sua etiologia são: predisposição genética (síndrome do nevo basocelular, síndrome de Bazex e xeroderma pigmentoso) 28 , exposição ao arsênico, fatores ambientais (hidrocarbonetos e pesticidas), imunossupressão, injúrias (queimadura e trauma), exposição à radiação ionizante 29 , fototipo baixo (cabelo, olhos e pele clara), sexo masculino, nevo sebáceo 30 , idade avançada, exposição solar e queimaduras na infância 31,32,33 .…”