Axillary recurrence after a tumour-negative sentinel node biopsy in breast cancer patients: A systematic review and meta-analysis of the literature

Ploeg, Iris M. C. van der; Nieweg, Omgo E.; Rijk, Maartje C. van; Olmos, Renato A. Valdés; Kroon, Bin B. R.

doi:10.1016/j.ejso.2008.01.034

Cited by 188 publications

(80 citation statements)

References 51 publications

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“…Sentinel node mapping for breast cancer has been performed safely without SPECT/CT and the rate of axillary recurrence after a negative sentinel node biopsy has been very low [14]. SPECT/CT should therefore be performed on specific indications only.…”

Section: Journal Of Surgical Oncologymentioning

confidence: 99%

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SPECT/CT for preoperative sentinel node localization

Vermeeren

Ploeg

Olmos

et al. 2010

Journal of Surgical Oncology

118

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The value of SPECT/CT for detection and localization of sentinel nodes is reviewed. SPECT/CT depicts extra sentinel nodes and identifies nonnodal tracer accumulation. SPECT/CT is indicated in patients with complex lymphatic drainage as often present in patients with head, neck and scapular melanoma, breast cancer patients with extra-axillary sentinel nodes and patients with tumors draining to pelvic nodes. SPECT/CT also clarifies the drainage pattern of inconclusive conventional images (non-visualization or unclear location of the nodes).

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Section: Journal Of Surgical Oncologymentioning

confidence: 99%

“…Sentinel node biopsy based on conventional images has been carried out in breast cancer patients with good detection rates and rare false-negative results [14]. In melanoma, identification rate is close to 100% but the false negative rate is typically between 10% and 20% [15].…”

Section: Conventional Imaging Techniquesmentioning

confidence: 99%

SPECT/CT for preoperative sentinel node localization

Vermeeren

Ploeg

Olmos

et al. 2010

Journal of Surgical Oncology

118

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“…reports have discussed the protocols and technical details of accurate scintigraphic SLN mapping [2,23]. One difficulty associated with conventional planar imaging is to preoperatively identify the exact anatomic localization of the detected nodes.…”

Section: Discussionmentioning

confidence: 99%

The Clinical Value of Hybrid Sentinel Lymphoscintigraphy to Predict Metastatic Sentinel Lymph Nodes in Breast Cancer

Kim

et al. 2014

Nucl Med Mol Imaging

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Purpose Hybrid imaging techniques can provide functional and anatomical information about sentinel lymph nodes in breast cancer. Our aim in this study was to evaluate which imaging parameters on hybrid sentinel lymphoscintigraphy predicted metastatic involvement of sentinel lymph nodes (SLNs) in patients with breast cancer. Methods Among 56 patients who underwent conventional sentinel lymphoscintigraphy, 45 patients (age, 53.1±9.5 years) underwent hybrid sentinel lymphoscintigraphy using a singlephoton emission computed tomography (SPECT)/computed tomography (CT) gamma camera. On hybrid SPECT/CT images, we compared the shape and size (long-to-short axis [L/S] ratio) of the SLN, and SLN/periareolar injection site (S/P) count ratio between metastatic and non-metastatic SLNs. Metastatic involvement of sentinel lymph nodes was confirmed by pathological biopsy. Results Pathological biopsy revealed that 21 patients (46.7 %) had metastatic SLNs, while 24 (53.3 %) had non-metastatic SLNs. In the 21 patients with metastatic SLNs, the SLN was mostly round (57.1 %) or had an eccentric cortical rim (38.1 %). Of 24 patients with non-metastatic SLNs, 13 patients (54.1 %) had an SLN with a C-shape rim or eccentric cortex. L/S ratio was 2.04 for metastatic SLNs and 2.38 for non-metastatic SLNs. Seven (33 %) patients had T1 primary tumors and 14 (66 %) had T2 primary tumors in the metastatic SLN group. In contrast, 18 (75 %) patients had T1 primary tumors and six (25 %) had T2 tumors in the non-metastatic SLN group. S/P count ratio was significantly lower in the metastatic SLN group than the non-metastatic SLN group for those patients with a T1 primary tumor (p=0.007). Conclusions Hybrid SPECT/CT offers the physiologic data of SPECT together with the anatomic data of CT in a single image. This hybrid imaging improved the anatomic localization of SLNs in breast cancer patients and predicted the metastatic involvement of SLNs in the subgroup of breast cancer patients with T1 primary tumors.

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“…A negative SLNB in breast cancer exposes to 0.3% axillary recurrence only, within a median delay of 20 months (range 4 -63) [29]. So the follow-up reported in table 1 (range 15 -46) could be an element for assessing that false negative results after second SLNB were controlled.…”

Section: Discussionmentioning

confidence: 99%

“…Simultaneous neoplasms with only one of them detected can expose either to collision tumour or destruction of lymphatic pathways leading to a second metastatic undetected SN. In case of breast cancer a median delay of 20 months [29] would be necessary and only weeks for melanoma in order to observe a clinically or radiologically enlarged lymph node.…”

Section: To What Extent Previous Surgery and Lymphatic Dissection (Slmentioning

confidence: 99%

Axillary Sentinel Lymph Node Biopsy for Breast Cancer and Melanoma Patients after Previous Axillary Surgery: A Systematic Review

Matter¹,

Romy²,

Boubaker³

et al. 2013

JCT

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Objective: Sentinel lymph node biopsy (SLNB) is a validated staging technique for breast carcinoma. Some women are exposed to have a second SLNB due to breast cancer recurrence or a second neoplasia (breast or other). Due to modified anatomy, it has been claimed that previous axillary surgery represents a contra-indication to SLNB. Our objective was to analyse the literature to assess if a second SLNB is to be recommended or not. Methods: For the present study, we performed a review of all published data during the last 10 years on patients with previous axilla surgery and second SLNB. Results: Our analysis shows that second SLNB is feasible in 70%. Extra-axillary SNs rate (31%) was higher after radical lymph node dissection (ALND) (60% -84%) than after SLNB alone (14% -65%). Follow-up and complementary ALND following negative and positive second SLNB shows that it is a reliable procedure. Conclusion: The review of literature confirms that SLNB is feasible after previous axillary dissection. Triple technique for SN mapping is the best examination to highlight modified lymphatic anatomy and shows definitively where SLNB must be performed. Surgery may be more demanding as patients may have more frequently extra-axillary SN only, like internal mammary nodes. ALND can be avoided when second SLNB harvests negative SNs. These conclusions should however be taken with caution because of the heterogeneity of publications regarding SLNB and surgical technique.

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Axillary recurrence after a tumour-negative sentinel node biopsy in breast cancer patients: A systematic review and meta-analysis of the literature

Cited by 188 publications

References 51 publications

SPECT/CT for preoperative sentinel node localization

SPECT/CT for preoperative sentinel node localization

The Clinical Value of Hybrid Sentinel Lymphoscintigraphy to Predict Metastatic Sentinel Lymph Nodes in Breast Cancer

Axillary Sentinel Lymph Node Biopsy for Breast Cancer and Melanoma Patients after Previous Axillary Surgery: A Systematic Review

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