Axis-I disorders and vulnerability to psychosis

Svirskis, T.; Korkeila, Jyrki; Heinimaa, Markus; Huttunen, Jukka; Ilonen, Tuula; Ristkari, Terja; McGlashan, Thomas H.; Salokangas, Raimo K. R.

doi:10.1016/j.schres.2004.11.002

Cited by 82 publications

(68 citation statements)

References 21 publications

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“…However, hippocampal volumes are not consistently reduced in other UHR studies-including those imaged at 3 T (Stone et al, 2009)-which suggests that although hippocampal volumes may be reduced in UHR populations, they are not related to transition nor the risk syndrome itself (or if volume is reduced, it is only in subregions (Witthaus et al, 2010)). Reductions in hippocampal volume have been reported in a number of psychiatric disorders, notably major depression (McKinnon et al, 2009), which is very common in UHR cohorts (eg Svirskis et al, 2005). There may also be an association with the proportion of each sample that have a family history of schizophrenia (Boos et al, 2007), although in our own work we do not find this-rather, we found that those with a positive family history tended to have preserved hippocampal volume .…”

Section: Hippocampal Volumecontrasting

confidence: 52%

Hippocampal pathology in individuals at ultra-high risk for psychosis: A multi-modal magnetic resonance study

et al. 2010

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Section: Hippocampal Volumecontrasting

confidence: 52%

Hippocampal pathology in individuals at ultra-high risk for psychosis: A multi-modal magnetic resonance study

et al. 2010

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“…33 Rosen et al, 34 for example, reported that in a sample of clinically presenting individuals who met criteria for a prodromal risk syndrome, 76% had at least one diagnosable lifetime Axis 1 disorder. Svirskis et al, 35 similarly, reported that over 90% of help-seeking individuals who met criteria for a prodromal risk syndrome had at least one comorbid disorder. Depressive disorders were the most common diagnosis in both studies, as in the current report.…”

Section: Discussionmentioning

confidence: 99%

Identification and Characterization of Prodromal Risk Syndromes in Young Adolescents in the Community: A Population-Based Clinical Interview Study

Kelleher

Murtagh

Molloy

et al. 2011

Schizophrenia Bulletin

134

145

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While a great deal of research has been conducted on prodromal risk syndromes in relation to help-seeking individuals who present to the clinic, there is a lack of research on prodromal risk syndromes in the general population. The current study aimed first to establish whether prodromal risk syndromes could be detected in non-help-seeking community-based adolescents and secondly to characterize this group in terms of Axis-1 psychopathology and general functioning. We conducted in-depth clinical interviews with a population sample of 212 school-going adolescents in order to assess for prodromal risk syndromes, Axis-1 psychopathology, and global (social/occupational) functioning. Between 0.9% and 8% of the community sample met criteria for a risk syndrome, depending on varying disability criteria. The risk syndrome group had a higher prevalence of co-occurring nonpsychotic Axis-1 psychiatric disorders (OR 5 4.77, 95% CI 5 1.81-12.52; P < .01) and poorer global functioning (F 5 24.5, df 5 1, P < .0001) compared with controls. Individuals in the community who fulfill criteria for prodromal risk syndromes demonstrate strong similarities with clinically presenting risk syndrome patients not just in terms of psychotic symptom criteria but also in terms of co-occurring psychopathology and global functioning.

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“…33% erhielten jedoch im PAS bzw. OASIS insgesamt weniger Risikopersonen keine zusätzliche psychiatrische Diagnose [2,3] dien mit dem SKID I zur "Ko"-Morbidität im potentiellen Prodrom gestützt, die durchweg hohe Raten insbesondere von depressiven Störungen zwischen 28% [35] und 83% [42] sowohl für Patienten mit UHR-als auch solchen mit Basissymptomkriterien berichten [35,39,42].…”

Section: Verteilung Von Nichtpsychotischen Psychiatrischen Diagnosenunclassified

Das Kölner Früh-Erkennungs- & Therapie-Zentrum für psychische Krisen (FETZ)

Schultze‐Lutter¹,

Picker²,

Ruhrmann³

et al. 2008

Med Klin

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Axis-I disorders and vulnerability to psychosis

Cited by 82 publications

References 21 publications

Hippocampal pathology in individuals at ultra-high risk for psychosis: A multi-modal magnetic resonance study

Hippocampal pathology in individuals at ultra-high risk for psychosis: A multi-modal magnetic resonance study

Identification and Characterization of Prodromal Risk Syndromes in Young Adolescents in the Community: A Population-Based Clinical Interview Study

Das Kölner Früh-Erkennungs- & Therapie-Zentrum für psychische Krisen (FETZ)

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