2010
DOI: 10.1016/s1937-6448(10)83003-5
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Axonal Ensheathment and Intercellular Barrier Formation in Drosophila

Abstract: Glial cells are critical players in every major aspect of nervous system development, function, and disease. Other than their traditional supportive role, glial cells perform a variety of important functions such as myelination, synapse formation and plasticity, and establishment of blood–brain and blood–nerve barriers in the nervous system. Recent studies highlight the striking functional similarities between Drosophila and vertebrate glia. In both systems, glial cells play an essential role in neural ensheat… Show more

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Cited by 12 publications
(13 citation statements)
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References 141 publications
(344 reference statements)
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“…In the late larva, one can distinguish perineurial glia and subperineurial glia, the latter forming the septate junction seal (Banerjee et al, 2006; Stork et al, 2008; Blauth et al, 2010). As in the CNS, the subperineurial layer is responsible for the blood brain barrier.…”
Section: Glial Morphology In the Adult And Larval Brainmentioning
confidence: 99%
“…In the late larva, one can distinguish perineurial glia and subperineurial glia, the latter forming the septate junction seal (Banerjee et al, 2006; Stork et al, 2008; Blauth et al, 2010). As in the CNS, the subperineurial layer is responsible for the blood brain barrier.…”
Section: Glial Morphology In the Adult And Larval Brainmentioning
confidence: 99%
“…Importantly, vertebrate TJs are found between the myelin sheaths of the extended plasma membrane of oligodendrocytes, an observation made more than 40 years ago ( Bronstein and Tiwari-Woodruff, 2006 ), suggesting that vertebrate TJs (the radial component of myelinated axons) are the sites where the membrane components of myelin sheaths are organized ( Dermietzel and Kroczek, 1980 ). Similarly, ladder-like SJs form between the outer and inner glial cell membranes that provide the same insulating function as the myelinating oligodendrocytes and Schwann cells of vertebrates ( Banerjee and Bhat, 2008 ; Banerjee et al, 2006 ; Blauth et al, 2010 ). Thus, a clear precedent exists for adding membrane to vertebrate TJs and insect SJs during normal development.…”
Section: Discussionmentioning
confidence: 99%
“…Two types of neuropil glia are present in Drosophila: ensheathing glia, which surround the synaptic neuropil, and astrocyte-like glia that infiltrate into the inner region of the neuropil volume. Finally, CNSderived peripheral glia are also subcategorized into three types [3][4][5]16] . The innermost type in contact with axons is termed wrapping glia; this is also considered to be a subtype of neuropil glia due to its association with nerves.…”
Section: Drosophila Gliamentioning
confidence: 99%
“…Nonetheless, compelling evidence has demonstrated that glia participate actively in mediating a number of neuronal events such as axon guidance, peripheral axon ensheathment, and formation of the blood-brain barrier to protect the central nervous system (CNS) [1][2][3][4][5] . On the other hand, a tripartite model that includes glia has recently been proposed to revise the classical view of synaptic structure [6][7][8] .…”
mentioning
confidence: 99%