“…Various hypotheses suggest that the process of cavernous degeneration is related to lysozyme activity (Kao et al, 1977), pulsatile hydrodynamics (Williams et al, 1981), inflammation, macrophage activation, and subsequent astrocyte migration (Fitch et al, 1999). Microglia, the intrinsic brain macrophages, secrete EGF after CNS injury (Briers et al, 1994;Nolte et al, 1997).…”