1977
DOI: 10.1016/0014-4886(77)90259-x
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Axonal regeneration across transected mammalian spinal cords: An electron microscopic study of delayed microsurgical nerve grafting☆

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Cited by 165 publications
(33 citation statements)
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“…Various hypotheses suggest that the process of cavernous degeneration is related to lysozyme activity (Kao et al, 1977), pulsatile hydrodynamics (Williams et al, 1981), inflammation, macrophage activation, and subsequent astrocyte migration (Fitch et al, 1999). Microglia, the intrinsic brain macrophages, secrete EGF after CNS injury (Briers et al, 1994;Nolte et al, 1997).…”
Section: Discussionmentioning
confidence: 99%
“…Various hypotheses suggest that the process of cavernous degeneration is related to lysozyme activity (Kao et al, 1977), pulsatile hydrodynamics (Williams et al, 1981), inflammation, macrophage activation, and subsequent astrocyte migration (Fitch et al, 1999). Microglia, the intrinsic brain macrophages, secrete EGF after CNS injury (Briers et al, 1994;Nolte et al, 1997).…”
Section: Discussionmentioning
confidence: 99%
“…However, access of SCs to the CNS is prevented by astrocytes at the peripheral nerve entry zones, and astrocytes restrict SCs migration following transplantation (Blakemore and Patterson, 1975;Blakemore et al, 1986;Sims et al, 1985). SCs or peripheral nerve grafts to the CNS induced the regeneration of axons, but neurites attempting to leave the SCs environment of the graft and reenter host CNS tissue failed to traverse the SCs-astrocyte interface (Kao et al, 1977;Xu et al, 1997). Similarly, sensory axon regeneration terminated at the astrocyte-SCs transitional zone (Carlstedt, 1997).…”
Section: Introductionmentioning
confidence: 93%
“…Kao et a1 [8] have studied the spinal cord injury site after transection in dogs. While their focus was on the surgical technique they use to assist regrowth of axons, their electron micrographs showed that some regenerating axons appeared to be turned back by a sheet of BL.…”
Section: Bl Margination Phenomenonmentioning
confidence: 99%