1999
DOI: 10.1002/(sici)1096-9861(19990809)410:4<612::aid-cne8>3.0.co;2-r
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Axonal regeneration of descending brain neurons in larval lamprey demonstrated by retrograde double labeling

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Cited by 25 publications
(19 citation statements)
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“…Thus, some axotomized neurons that did not recover normal firing patterns appeared to regenerate their axons but perhaps not far enough to make substantial numbers of synapses below the lesion (see Discussion). For example, at relatively long recovery times (16 weeks) after complete transections of the rostral spinal cord, only ϳ30 -50% of the large B cells (B1, B3, and B4) regenerate their axons for at least ϳ10 mm below the lesion (Davis and McClellan, 1994b) (also see Zhang and McClellan, 1999).…”
Section: Firing Patterns Of Identified Rs Neuronsmentioning
confidence: 99%
“…Thus, some axotomized neurons that did not recover normal firing patterns appeared to regenerate their axons but perhaps not far enough to make substantial numbers of synapses below the lesion (see Discussion). For example, at relatively long recovery times (16 weeks) after complete transections of the rostral spinal cord, only ϳ30 -50% of the large B cells (B1, B3, and B4) regenerate their axons for at least ϳ10 mm below the lesion (Davis and McClellan, 1994b) (also see Zhang and McClellan, 1999).…”
Section: Firing Patterns Of Identified Rs Neuronsmentioning
confidence: 99%
“…After possible regeneration, a second tracer is applied below the transection site but above the application site for the first tracer. Although there are some inherent limitations to double‐labeling experiments (see discussion in Zhang and McClellan, 1999a), ideally, double‐labeled neurons regenerated their axons, whereas neurons labeled only with the second tracer were uninjured and subsequently elongated their axons through the lesion site. Following spinal cord injury in salamander, zebrafish, embryonic chick, young opossum, or neonatal rat, double labeling of descending brain neurons is in the range of approximately 5–45% (Davis et al, 1989; Garner et al, 1990; Xu and Martin, 1991; Bates and Stelzner, 1993; Hasan et al, 1993; Becker et al, 1997; Wang et al, 1998).…”
mentioning
confidence: 99%
“…Results from double‐labeling experiments indicate that many descending brain neurons, including unidentified reticulospinal (RS) neurons that are thought to initiate locomotion, regenerate their axons following spinal cord transection (Zhang and McClellan. 1999a). However, these previous studies do not exclude the possibility that restoration of brain‐spinal cord projections following spinal cord injury might also be due to the addition of new descending projections.…”
mentioning
confidence: 99%
“…Cell body responses probably play a role in enhancing restoration of descending brain-spinal cord projections in larval lamprey with CLs. Recent studies strongly suggest that axonal regeneration is the major mechanism for restoration of descending brain-spinal cord projections and recovery of locomotor function in spinal cord-transected larval lamprey (Zhang and McClellan, 1999;Zhang et al, 2002). Thus, a better understanding of the mechanisms underlying the enhancement of axonal regeneration by CLs might suggest possible strategies for regulating regeneration under conditions in which axonal outgrowth is limited.…”
Section: Discussionmentioning
confidence: 99%