2007
DOI: 10.1167/iovs.06-1002
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Axonal Transport and Cytoskeletal Changes in the Laminar Regions after Elevated Intraocular Pressure

Abstract: Elevated IOP induced both axonal transport and cytoskeleton changes in the optic nerve head. Changes to the cytoskeleton may contribute to the axonal transport abnormalities that occur in elevated IOP.

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Cited by 117 publications
(101 citation statements)
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References 31 publications
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“…RITC remains in RGCs for at least 30 days without extracellular leakage and is resilient to further IHC processing (K€ obbert et al, 2000;Thanos and Bonhoeffer, 1983). Balaratnasingam et al (2007Balaratnasingam et al ( , 2008 used RITC in conjunction with IHC for structural proteins to examine disruption of anterograde AT and changes in the axonal cytoskeleton simultaneously after acute IOP elevation in pig. RITC transport was disrupted in the ONH coupled with decreased staining for neurofilament, a major structural protein in the axon, between 3 and 6 h of IOP elevation (Balaratnasingam et al, 2007(Balaratnasingam et al, , 2008.…”
Section: Application Of Actively Transported Moleculesmentioning
confidence: 99%
“…RITC remains in RGCs for at least 30 days without extracellular leakage and is resilient to further IHC processing (K€ obbert et al, 2000;Thanos and Bonhoeffer, 1983). Balaratnasingam et al (2007Balaratnasingam et al ( , 2008 used RITC in conjunction with IHC for structural proteins to examine disruption of anterograde AT and changes in the axonal cytoskeleton simultaneously after acute IOP elevation in pig. RITC transport was disrupted in the ONH coupled with decreased staining for neurofilament, a major structural protein in the axon, between 3 and 6 h of IOP elevation (Balaratnasingam et al, 2007(Balaratnasingam et al, , 2008.…”
Section: Application Of Actively Transported Moleculesmentioning
confidence: 99%
“…This may cause direct mechanical injury to the axons, as they are compressed against this rigid structure. Indeed, blockage of axonal transport has been identified in the region of the lamina cribrosa (Quigley and Addicks 1980;Johansson 1983Johansson , 1988Balaratnasingam et al 2007). This may lead to an interruption of retrograde transport of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), to the ganglion cell body, followed by degeneration of the cell Quigley et al 2000).…”
Section: Gene Expression In the Onh In Glaucomamentioning
confidence: 99%
“…The lamina cribrosa (LC) within the scleral canal in the optic nerve head (ONH) is thought to be the primary site of axonal damage in glaucoma. 2,3 Hence, understanding the effects of IOP on the ONH, and on the LC in particular, has been an interest for many years. 1,[3][4][5][6] Both experimental 3,[7][8][9][10][11] and modeling 5,[12][13][14][15][16][17][18][19][20] studies have described effects of IOP on the ONH which are complex, involving multiple factors having nonlinear effects and which interact in complicated ways.…”
mentioning
confidence: 99%