Axons-on-a-chip for mimicking non-disruptive diffuse axonal injury underlying traumatic brain injury

Pan, Xiaorong; Li, Jie; Li, Wei; Wang, Haofei; Durisic, Nela; Li, Zhenyu; Feng, Yu; Liu, Yifan; Zhao, Chun‐Xia; Wang, Tong

doi:10.1039/d2lc00730d

Cited by 8 publications

(2 citation statements)

References 54 publications

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“…151 The TBI-caused stretch and shear forces break and disassemble the axonal cytoskeleton. [152][153][154] The stretch on the membrane helps remove the Mg 2+ that blocks the channel of NMDAR and thus activates them. 5,155,156 The NMDAR-mediated Ca 2+ influx participates in the formation of the beadings after traumatic axonal injury, but the detailed mechanisms are not clear.…”

Section: Nmdar and Trpv4 Mediate Excitotoxicity Caused By Extreme Mec...mentioning

confidence: 99%

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Mechanobiological insight into brain diseases based on mechanosensitive channels: Common mechanisms and clinical potential

Li,

Zhao,

Tian

et al. 2024

CNS Neurosci Ther

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BackgroundAs physical signals, mechanical cues regulate the neural cells in the brain. The mechanosensitive channels (MSCs) perceive the mechanical cues and transduce them by permeating specific ions or molecules across the plasma membrane, and finally trigger a series of intracellular bioelectrical and biochemical signals. Emerging evidence supports that wide‐distributed, high‐expressed MSCs like Piezo1 play important roles in several neurophysiological processes and neurological disorders.AimsTo systematically conclude the functions of MSCs in the brain and provide a novel mechanobiological perspective for brain diseases.MethodWe summarized the mechanical cues and MSCs detected in the brain and the research progress on the functional roles of MSCs in physiological conditions. We then concluded the pathological activation and downstream pathways triggered by MSCs in two categories of brain diseases, neurodegenerative diseases and place‐occupying damages. Finally, we outlined the methods for manipulating MSCs and discussed their medical potential with some crucial outstanding issues.ResultsThe MSCs present underlying common mechanisms in different brain diseases by acting as the “transportation hubs” to transduce the distinct signal patterns: the upstream mechanical cues and the downstream intracellular pathways. Manipulating the MSCs is feasible to alter the complicated downstream processes, providing them promising targets for clinical treatment.ConclusionsRecent research on MSCs provides a novel insight into brain diseases. The common mechanisms mediated by MSCs inspire a wide range of therapeutic potentials targeted on MSCs in different brain diseases.

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Section: Nmdar and Trpv4 Mediate Excitotoxicity Caused By Extreme Mec...mentioning

confidence: 99%

“…The TBI‐caused stretch and shear forces break and disassemble the axonal cytoskeleton 152–154 . The stretch on the membrane helps remove the Mg 2+ that blocks the channel of NMDAR and thus activates them 5,155,156 .…”

Section: The Mscs Respond To Forces From Place‐occupying Damagementioning

confidence: 99%

Mechanobiological insight into brain diseases based on mechanosensitive channels: Common mechanisms and clinical potential

Li,

Zhao,

Tian

et al. 2024

CNS Neurosci Ther

View full text Add to dashboard Cite

show abstract

Fabrication of device equipped with rope-like axon bundles by diamond-like carbon thin film patterning deposition

Ban,

Ito,

Endo

2024

Diamond and Related Materials

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Molecular biomarkers of diffuse axonal injury: recent advances and future perspectives

Zhang,

Li,

Wang

et al. 2024

Expert Review of Molecular Diagnostics

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Axons-on-a-chip for mimicking non-disruptive diffuse axonal injury underlying traumatic brain injury

Abstract: Diffuse axonal injury (DAI) is the most severe pathological feature of traumatic brain injury (TBI). However, how primary axonal injury is induced by transient mechanical impacts remains unknown, mainly due...

Cited by 8 publications

References 54 publications

Mechanobiological insight into brain diseases based on mechanosensitive channels: Common mechanisms and clinical potential

Mechanobiological insight into brain diseases based on mechanosensitive channels: Common mechanisms and clinical potential

Fabrication of device equipped with rope-like axon bundles by diamond-like carbon thin film patterning deposition

Molecular biomarkers of diffuse axonal injury: recent advances and future perspectives

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