2013
DOI: 10.1073/pnas.1211990110
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Aye-aye population genomic analyses highlight an important center of endemism in northern Madagascar

Abstract: We performed a population genomics study of the aye-aye, a highly specialized nocturnal lemur from Madagascar. Aye-ayes have low population densities and extensive range requirements that could make this flagship species particularly susceptible to extinction. Therefore, knowledge of genetic diversity and differentiation among aye-aye populations is critical for conservation planning. Such information may also advance our general understanding of Malagasy biogeography, as aye-ayes have the largest species dist… Show more

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Cited by 43 publications
(34 citation statements)
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“…Transcriptome data revealed relatively high genetic diversity in this group compared to Simian primates, with the exception of aye-ayes (Daubentonia madagascariensis; π ≈ 7.2 × 10 −4 ), whose genetic diversity was found to be similar to or lower than non-African humans (Perry et al, 2012). The estimate of genetic diversity in aye-ayes using transcriptome data is consistent with estimates obtained using data from whole-genome resequencing (Perry et al, 2013). The following estimates of π have been made for the other members of this group: 2.8 × 10 −3 in crowned lemur (Eulemur coronatus), 2.4 × 10 −3 in mongoose lemur (E. mongoz), 3.7 × 10 −3 in black-and-white ruffed lemur (Varecia variegata), 2.1 × 10 −3 in slow loris (Nycticebus coucang), 2.0 × 10 −3 in mohol bushbaby (Galago moholi), and 6.8 × 10 −3 in Coquerel's sifaka (Propithecus verreauxi coquereli) (Perry et al, 2012).…”
Section: Prosimians (Lemuriformes and Tarsiiformes)supporting
confidence: 82%
“…Transcriptome data revealed relatively high genetic diversity in this group compared to Simian primates, with the exception of aye-ayes (Daubentonia madagascariensis; π ≈ 7.2 × 10 −4 ), whose genetic diversity was found to be similar to or lower than non-African humans (Perry et al, 2012). The estimate of genetic diversity in aye-ayes using transcriptome data is consistent with estimates obtained using data from whole-genome resequencing (Perry et al, 2013). The following estimates of π have been made for the other members of this group: 2.8 × 10 −3 in crowned lemur (Eulemur coronatus), 2.4 × 10 −3 in mongoose lemur (E. mongoz), 3.7 × 10 −3 in black-and-white ruffed lemur (Varecia variegata), 2.1 × 10 −3 in slow loris (Nycticebus coucang), 2.0 × 10 −3 in mohol bushbaby (Galago moholi), and 6.8 × 10 −3 in Coquerel's sifaka (Propithecus verreauxi coquereli) (Perry et al, 2012).…”
Section: Prosimians (Lemuriformes and Tarsiiformes)supporting
confidence: 82%
“…These results indicate that half of the participants did not have access to the Internet, even with help from family members, when they wanted to collect information regarding diabetes care. This rate was much lower than the nationally reported rate of 78.2% of the population having access to the Internet at the end of 2010 [30]. …”
Section: Resultsmentioning
confidence: 70%
“…As the relationship becomes longer, the number of prescribed drugs, insulin use, and diabetes complications could affect the goal of diabetes education, and the communications could be tailored to these conditions. Some factors, such as social support [29], could be positively associated with the patient’s self-efficacy for diabetes management, while other factors, including the widening use of the Internet [30,31], could affect a patient’s HL and diabetes care. The Internet is frequently used to acquire health-related information in some populations [32-34], and patients may use the Internet to learn about their diseases and how to perform self-care [35].…”
Section: Introductionmentioning
confidence: 99%
“…Nonetheless, neither set of sequences contains disruptive mutations in coding sequences, and can be easily aligned to closely related and well-characterised herpesvirus genomes. The exogenous status of DmRV1 is further supported by the lack of any detectable viral sequences in the recently released re-sequencing project of 12 aye-aye individuals [67]. Both BLAST and read-mapping techniques were employed to search for HVL sequences in the other genomes, with no reportable matches.…”
Section: Discussionmentioning
confidence: 99%