Ayurveda in changing scenario of diabetes management for developing safe and effective treatment choices for the future

Abstract

Ayurveda described diabetes mellitus (DM) as Madhumeha. This ancient evidence-based system of medicine enumerated various herbs and formulations for its management, which needs scientific validation. Whereas translational "bedside to bench" approach in biomedical research is an upcoming concept, its application in traditional and complementary medicine can be interesting. The intersecting concepts in the field Ayurveda and translational research needs "omics" approach. The Ayurvedic biology concepts about DM have its close relations with present systems biology approach. Metabolic changes causing tissue damage connected with genetic and immunological irregularities leading to insulin resistance coincide with ancient knowledge. Combinatorial therapy according to Prakriti type as elucidated by Ayurgenomics should be carried on for further research. "Bedside to bench" approaches in research utilizing metabolomics and pharmacogenomics approach can be a major step towards changing the therapeutic strategy towards diabetes. Prameha which is described as the pre-diabetic state is a novel concept in Ayurvedic etiopathogenesis, while metabolomic parameters like lipid level in urine can be a thrust area of research to have a pre-diabetic screening method in high-risk populations. This tradition-guided research paradigm can open up novel opportunities in traditional knowledge-inspired systems biology and drug discovery against diabetes.

Role of ayurveda detoxification and dietary modification on restoration of euglycemia in T2DM patients

“…Clinical trials should be the first step in research to incorporate the concepts of the role of dietary intake. 2,8 Hence, the present study sought to assess restoration of carbohydrate metabolism in known type 2 diabetes patients to achieve good glycemic control without dependency on oral antihyperglycemic agents. Our study findings are in line with that of previous studies in which the CDC program was advised.…”

“…Long-term effects of diabetes are decreased functioning of the heart, kidneys, eyes, and nervous system which becomes fatal if untreated. 2 Diabetes is expected to affect 552 million by 2030 according to the International Diabetes Federation (IDF). In India, prevalence of type 2 diabetes is rapidly accelerating with more people suffering from this disease than any other country.…”

Overview of Diabetes Mellitus and its Treatment

“…The Avocado, oats, sweet corn, apples with skin and blue barriers contain fibre source which is good for diabetes control. [25] highlighted that, Ayurveda treatment is the best and deep method medication for diabetes. This way of treatment maintains the blood sugar level by regular intake of Ayurveda medicine.…”

Effect Ayurveda-based Comprehensive Diabetic Care Program on Glycemic Control in Type 2 Diabetic Mellitus Patients: An Observational Study

“…Ayurveda is an ancient evidence-based medicinal practice that uses several herbal formulations and therapeutic measures such as Panchakarma including meditation and Yogic exercises to avert, alleviate and manage diabetes according to individual patients [3].…”