Āyurvedic herbal drugs with possible cytostatic activity

Smit, H. Friso; Woerdenbag, Herman J.; Singh, R. P.; Meulenbeld, G. J.; Labadie, R. P.; Zwaving, J. H.

doi:10.1016/0378-8741(95)01255-c

Cited by 99 publications

(46 citation statements)

References 15 publications

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“…Calotropis does not act as an antidote for scorpion sting (Uawonggul et al .2006) but it was locally used in scorpion sting in study area. Acorus calamus was reported to be used as pesticide in study area and anticancer in the ayurveda but the experiment showed its insignificant inhibitory effect (Smit et al 1995). Because of the bitter alkaloids of Swertia chirayita, it is beneficial to the indigestion (Reynolds 1982) but it was used only for headache and fever in study area.…”

Section: Discussionmentioning

confidence: 99%

Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

Kunwar

Uprety

Burlakoti

et al. 2009

Ethnobot. Res. App.

346

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Ethnopharmacological knowledge is common and import among tribal populations but much of the information is empirical at best lacking scientific validation. Despite widespread use of plant resources in traditional medicines, bioassay analysis of very few plant species have been conducted to investigate their medicinal properties, and to ascertain safety and efficacy of traditional remedies. The present study analyses indigenous uses of medicinal plants of far-west Nepal and compares with earlier ayurveda studies, phytochemical assessments and pharmacological actions. A field study was carried out in Baitadi and Darchula districts of far-west Nepal. Group discussions, informal meetings, questionnaire surveys and field observations were employed for primary data collection. Voucher specimens were collected with field notes and codes and deposited at Tribhuvan University Central Herbarium (TUCH), Kathmandu. Only 50% of species surveyed shared common uses with ayurvedic medicine. This implies that these herbal remedies are part of an independent health care system in the Nepal Himalaya, which is indigenous and influenced by ayurveda. The folk uses of some of the species were contradicting to those of ayurveda and phytochemical bioassays. A detailed phytochemical study on those species would be an important line of research. IntroductionMedicinal plants help in alleviating human suffering and are widely used for subsistence, home remedies, and trade (Kunwar et al. 2006). It is estimated that 70-80% of people worldwide rely on traditional herbal medicine to meet their primary health care needs (Farnsworth & Soejarto 1991). The ayurveda is an ancient traditional system of medicine with remedies for health and alleviation of illness. The acceptance of the ayurveda is gearing up and use of indigenous drugs of natural/plant origin is a maPublished: January 16, 2009 Ethnobotany Research & Applications 6www.ethnobotanyjournal.org/vol7/i1547-3465-07-005.pdf cuna pruriens (L.) DC. for Parkinson's disease, Commiphora as a hypolipidemic, Asclepias as cardiotonic, psoralens for vitiligo, curcumines for inflammation, baccoside for mental retention, picrosides for hepatoprotective, diosgenin for the synthesis of steroidal hormones, guggulsterons as hypolipidemic, piperidine as bioavailability enhancers, asarone as hallucinogenic, phyllanthins as anti-virals, withanolides and many other steroidal lactones and their glycosides as immunomodulators (Jain 1994, Patwardhan 2000. As an example, the sale of drugs derived from the plant Taxus The increasing use of traditional therapies demands more scientifically sound evidence for the principles behind therapies and for effectiveness of medicines (Patwardhan et al. 2005). The therapies are often criticized due to dearth of research, critical evaluation, in vivo studies and validations (Fong 2002, Houghton 1995 to support the safety of uses. At the same time, ethnopharmacological knowledge is percolating down these days among the tribal population. The present study, therefore aim...

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Section: Discussionmentioning

confidence: 99%

Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

Kunwar

Uprety

Burlakoti

et al. 2009

Ethnobot. Res. App.

346

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“…(Fabaceae), conhecida popularmente como café berão e pó de mico, tem suas propriedades medicinais amplamente divulgadas em países asiáticos, especialmente a Índia. É uma espé-cie nativa de países tropicais, tais como a Índia, África e Ilhas do Pacífico, mas também ocorre no Brasil, sendo encontrada nas regiões da Amazônia, Cerrado e Mata Atlântica (MOTTA; PINTO, SCIO, 2012;RAJESHWAR et al, 2005;SMIT et al, 1995;TOZZI;AGOSTINI;SAZIMA, 2005).…”

Section: Introductionunclassified

Otimização do método extração de compostos fenólicos totais em sementes de Mucuna pruriens (L.) D.C.

Parmezan

Klein

Oliveira

et al. 2017

cmbio

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“…Some other authors have reported on the virulence of Yersinia strains in HeLa cells [18,19] and human epithelial (HEP 2) cells [10]. Similarly, the use of human intestinal cell lines such as Caco-2 and Colo-320 has also been reported for studying the invasion of enterovirulent strains of Y. pseudotuberculosis [3] and cytotoxicity of selected species [21]. As the process of invasiveness of the strain comprises attachment to the intestinal epithelial cell surface, leading to colonization, cell damage, internalization, disturbance of regulatory cell mechanisms and intracellular proliferation, an attempt was made in the present study to evaluate the virulence potential of Y. enterocolitica isolates from milk by cell invasion-inhibition assay.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the virulence potential ofYersinia enterocoliticaisolates from milk by cell invasion-inhibition assay

Kushal

Anand

2006

Lait

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-The psychrotrophic nature of Yersinia enterocolitica is of particular significance in milk and milk products that are normally refrigerated for considerable duration. Different virulence markers have been suggested to differentiate the non-virulent strains from virulent ones. The previous study conducted in our lab, however, failed to show any consistent correlation amongst these markers. As the process of invasiveness of the strain comprises attachment to the intestinal epithelial cell surface, leading to colonization, cell damage, internalization, disturbance of regulatory cell mechanisms and intracellular proliferation, an attempt was made in the present study to evaluate the virulence potential of Yersinia enterocolitica isolates from milk by cell invasion-inhibition assay. The present study revealed the presence of Y. enterocolitica in about 32.7% of the raw milk samples. Out of a total of about 36 confirmed isolates, only one isolate was found to be virulent based on the cell invasion-inhibition assay. d'invasion de la souche comporte l'adhésion à la surface des cellules épithéliales de l'intestin conduisant à la colonisation, à la lésion de la cellule, à l'internalisation, à la perturbation des mécanis-mes régulateurs de la cellule et à la prolifération intracellulaire, un essai a été mis en place dans la présente étude pour évaluer le potentiel de virulence d'isolats d'Yersinia enterocolitica provenant de lait par un test d'invasion-inhibition cellulaire. Les résultats révèlent la présence d'Yersinia enterocolitica dans environ 32,7 % des échantillons de lait cru. Sur un total de 36 isolats confirmés, un seul s'avérait être virulent. lait / Yersinia / virulence / test d'invasion-inhibition cellulaire

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Āyurvedic herbal drugs with possible cytostatic activity

Cited by 99 publications

References 15 publications

Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

Otimização do método extração de compostos fenólicos totais em sementes de Mucuna pruriens (L.) D.C.

Evaluation of the virulence potential ofYersinia enterocoliticaisolates from milk by cell invasion-inhibition assay

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