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Cited by 5 publications
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Background: World Health Organization states that antibacterial/antimicrobial resistance (AMR) can threaten the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses, and fungi. Objective: This review aims to discuss the plants and their derivatives having anti-corona virus/ viral activity. Methods: For the preparation of this review article, all the relevant information was gathered from accessible and inaccessible resources (Web, Books, Thesis, etc.). Results: It has been accepted worldwide that the uses of herbal products provide stronger immunity which helps to fight against these microbial species. SARS-CoV2 virus is now a pandemic, affecting many countries around the globe. This long series of herbal species may interfere with the target-specific proteins named S Protein, S protein-ACE-2 interaction, Helicase protein, N Protein, 3CL pr , PL pro to prevent the viral replication in the host. Traditional herbal medicine not only inhibits the virus attachment to the host body but also prevents replication and boosts up the host immune system. Natural remedies reduce the viral load and, in such conditions, the immunity becomes stronger, and so the patient can recover soon. Conclusion: The herbs-natural compounds with antiviral activity can effectively inhibit/blockade the CoV-host protein.Herbal medicine having immune boost-up property will play a major role as an anti-corona virus drug. INTRODUCTION:Coronavirus is a type of virus that relates to the large family of viruses that causes illness from the very normal cold conditions to headache, throat pain, breathing problems and can also lead to MERS and SARS 1 . Coronavirus has reached more than 210 countries around the globe. More than 2,46,79,975 positive cases have been recognized, while more than 8,36,721 peoples have lost their lives on 28th August 2020 2 .
Background: World Health Organization states that antibacterial/antimicrobial resistance (AMR) can threaten the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses, and fungi. Objective: This review aims to discuss the plants and their derivatives having anti-corona virus/ viral activity. Methods: For the preparation of this review article, all the relevant information was gathered from accessible and inaccessible resources (Web, Books, Thesis, etc.). Results: It has been accepted worldwide that the uses of herbal products provide stronger immunity which helps to fight against these microbial species. SARS-CoV2 virus is now a pandemic, affecting many countries around the globe. This long series of herbal species may interfere with the target-specific proteins named S Protein, S protein-ACE-2 interaction, Helicase protein, N Protein, 3CL pr , PL pro to prevent the viral replication in the host. Traditional herbal medicine not only inhibits the virus attachment to the host body but also prevents replication and boosts up the host immune system. Natural remedies reduce the viral load and, in such conditions, the immunity becomes stronger, and so the patient can recover soon. Conclusion: The herbs-natural compounds with antiviral activity can effectively inhibit/blockade the CoV-host protein.Herbal medicine having immune boost-up property will play a major role as an anti-corona virus drug. INTRODUCTION:Coronavirus is a type of virus that relates to the large family of viruses that causes illness from the very normal cold conditions to headache, throat pain, breathing problems and can also lead to MERS and SARS 1 . Coronavirus has reached more than 210 countries around the globe. More than 2,46,79,975 positive cases have been recognized, while more than 8,36,721 peoples have lost their lives on 28th August 2020 2 .
At present, sports injuries that occur during the practice of a sport or physical exercise are becoming more and more common, due to a series of predisposing factors that make an individual more susceptible to suffer these injuries. In Cuba there is a high prevalence of articular affections of knees and ankles, with a high prevalence in people older than 60 years; in the province of Santiago de Cuba 45% of the total number of consultations correspond to soft tissue injuries. One of the applications of the electromagnetic field is in the treatment of different pathologies of the osteomuscular system (Soma). The objective of this work lies in the design of a magnetic bed with permanent magnets, in analogy to a circular Halbach type configuration for the treatment of different diseases of the soma, which consists of three main parts: the magnetic system, which generates magnetic induction for therapeutic purposes, the opening and closing system of the magnetic system, which allows the radial variation of the magnetic system and the patient-support bed system, which allows the positioning of the patient in the treatment area. The principle of operation is that the therapist selects the induction of the magnetic field and the homogeneity of the magnetic field, depending on the pathology(s) to be treated, through a software that controls the movement of the opening and closing system of the magnetic system and the patient-bed support system, which is coupled to a stepper motor reducer that ensures a precise and accurate positioning of the sample (or patient) according to the area to be treated, which allows more than 80% effectiveness of the therapy with respect to conventional treatment.
Seventeen methanol extracts from different plant parts of five different Cassia species, including C. timorensis, C. grandis, C. fistula, C. spectabilis, and C. alata were screened against acetylcholinesterase (AChE). C. timorensis extracts were found to exhibit the highest inhibition towards AChE whereby the leaf, stem, and flower methanol extracts showed 94–97% inhibition. As far as we are aware, C. timorensis is one of the least explored Cassia spp. for bioactivity. Further fractionation led to the identification of six compounds, isolated for the first time from C. timorensis: 3-methoxyquercetin (1), benzenepropanoic acid (2), 9,12,15-octadecatrienoic acid (3), β-sitosterol (4), stigmasterol (5), and 1-octadecanol (6). Compound 1 showed moderate inhibition towards AChE (IC50: 83.71 μM), while the other compounds exhibited poor to slightly moderate AChE inhibitory activity. Molecular docking revealed that the methoxy substitution of 1 formed a hydrogen bond with TYR121 at the peripheral anionic site (PAS) and the hydroxyl group at C5 formed a covalent hydrogen bond with ASP72. Additionally, the OH group at the C3′ position formed an interaction with the protein at the acyl pocket (PHE288). This possibly explains the activity of 1 in blocking the entry of acetylcholine (ACh, the neurotransmitter), thus impeding the hydrolysis of ACh.
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