Abstract:Herein, we report the development of a novel route to tricyclic lactam products via a facile aza-[4+2] cycloaddition of catalytically generated acyliminium ions. Employing a Ca(NTf2)2 / nBu4NPF6 catalyst system...
A simple and efficient method for the synthesis of indolizin-3-ones through sequential Au(i)-catalyzed hydrocarboxylation, aminolysis, and cyclization, followed by ruthenium-catalyzed ring-closing metathesis.
A brand-new procedure for synthesis of 3-alkynylated 3,3-disubstituted isoindolinones has been disclosed via a HOTf or Fe(OTf)3-catalyzed dehydrative alkynylation of 3-hydroxyisoindolinones with terminal alkynes. Aryl, alkenyl and alkyl terminal alkynes...
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