Aza analogs of kainoids by dipolar cycloaddition*1

Di, Mingping

doi:10.1016/s0040-4039(04)00888-3

Cited by 1 publication

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“…Interestingly, a simultaneous 1,3-dipolar cycloaddition was observed, [49,50] and the diazomethane was also trapped by the highly activated, conjugated double bond to form a pyrazole ring system. [51] The presence of two nitrogen atoms was proven by the molecular formula C 18 H 28 N 2 O 7 as deduced from HREIMS and further supported by a positive reaction with the Dragendoff reagent, and a complete 1 H and 13 C NMR assignment based on 2D NMR spectra. In particular, the HMBC correlations from NH to C-2, C-3, C-9, from 9-H 2 to C-1, C-2, C-3, and from 2-H to C-1 and C-3, suggested the pyrazole ring substruc- ture.…”

Section: Resultsmentioning

confidence: 85%

Diversity of Antimicrobial Pyrenophorol Derivatives from an Endophytic Fungus, Phoma sp.

et al. 2008

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Keywords: Absolute configuration / Antimicrobial activity / Endophytic fungus / Macrodiolides / Phoma sp. / Pyrenophorol Pyrenophorol (1) and (-)-dihydropyrenophorin (3), two known macrodiolides, were isolated together with four new analogues (2, 4-6) and three ring-opened derivatives (7-9) from Phoma sp., an endophytic fungus isolated from Lycium intricatum from Gomera. The structures of the new compounds were elucidated by detailed spectroscopic analysis, comparison with reported data, and chemical interconversion. The absolute configurations were determined by chemical correlations and a modified Mosher's method. The diversity of these seven newly discovered metabolites not only ex-

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Section: Resultsmentioning

confidence: 85%