Aza-BODIPY photosensitizer substituted with phthalonitrile groups: Synthesis, photophysical properties and in vitro tests for breast cancer

Fluorescent poly(β-amino ester)s containing aza-BODIPYs as theranostic agents for bioimaging and photodynamic therapy

“…The spectral performance in the NIR region (650–900 nm) is characteristic of aza-BODIPYs. 17,34,69 Moreover, their molar absorptivity coefficients ( ε max ) were found to be 70 937 M −1 cm −1 (aza-BOD-OH) and 50 485 M −1 cm −1 (aza-BOD-DA). Such PSs exhibiting activity in the NIR region with high molar absorptivity coefficients are valuable for biomedical applications due to their enhanced tissue penetration.…”

Functionalized Aza-BODIPYs and Their Use in the Synthesis of Aza-BODIPY-Based Complex Systems

“…Gul and co-workers prepared aza-BODIPY 103 with phthalonitrile substituents by treatment of aza-BODIPY 101b with 4-[(3,4-dicyanophenyl)sulfanyl]benzoic acid in the presence of N -ethyl- N ′-(3-dimethylaminopropyl)carbodiimide (EDCI) and 4-( N , N -dimethylamino)pyridine (DMAP) in dry tetrahydrofuran under inert conditions at room temperature for 48 hours [Scheme 31 (ii)]. 54 Studies indicated that aza-BODIPY 103 can be used as a drug in various biological applications, as its effectiveness has been examined on the MCF-7 breast cancer cell line and the L929 cell line, a line of normally healthy cells.…”