Aza-phenol Based Macrocyclic Probes Design for “CHEF-on” Multi Analytes Sensor: Crystal Structure Elucidation and Application in Biological Cell Imaging

Abstract

Metal bound macrocyclic compounds found in biological systems inspired us to design and synthesize two Robson-type macrocyclic Schiff-base chemosensors, H 2 L1

A highly selective coumarin-based chemosensor for dual sensing of Cu2+ and Zn2+ ions with logic gate integration and live cell imaging

“…Furthermore, the chelation-enhanced uorescence (CHEF) effect causes an increase in emission intensity (Scheme 2). 36,37 The emission intensity at 509 nm decreases upon the introduction of Cu 2+ to the CIH due to the paramagnetic quenching effect caused by Cu 2+ . This paramagnetic ion with an empty d-shell is recognized well for its ability to signicantly reduce the emission intensity of a uorophore through the use of a photo-induced metal-to-uorophore electron transfer mechanism.…”

Tri-armed Schiff base fluorescent sensor for the rapid recognition of Zn(ii): application in live cell imaging, test strips and TLC

“…Nowadays, this technique is extensively employed for the detection and monitoring of Zn(II) in chemical, biological (including in vitro and in vivo imaging of biological samples) and environmental systems because of its simplicity and rapidity. 18,19 Cyanuric chloride (Cy$Cl), also known as 1,3,5-triazine, is a crucial scaffold for the synthesis of dendrimers, macrocycles and multifunctional libraries as it offers the sequential substitution of its three chlorine atoms. The threefold symmetry of the s-triazine core is an appealing feature in supramolecular chemistry due to its ability to make aromatic p-p stacking interactions and H-bond networks.…”