2012
DOI: 10.2169/internalmedicine.51.8167
|View full text |Cite
|
Sign up to set email alerts
|

Azacitidine-Induced Pneumonitis in a Patient with Myelodysplastic Syndrome: First Case Report in Japan

Abstract: A 74-year-old Japanese man with myelodysplastic syndrome (MDS) received chemotherapy with azacitidine. From the second day after starting the administration, he complained of fever, cough and shortness of breath. Chest roentgenography and computed tomography showed consolidations and ground-glass opacities. His symptoms grew from worse to life-threatening. We diagnosed him with azacitidine-induced pneumonitis and began administering corticosteroids. Thereafter, his symptoms and radiographic abnormalities impro… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
17
0

Year Published

2012
2012
2022
2022

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 13 publications
(17 citation statements)
references
References 22 publications
0
17
0
Order By: Relevance
“…All cases of azacitidine-induced pulmonary toxicity have been described as pneumonitis and eosinophilic pneumonia which are characterized by cough, lung infiltrates, and the presence of eosinophils in the alveolar spaces and pulmonary interstitium [12][13][14][15][16]. Chest CT in all cases showed bilateral airspace disease, nodular opacities, bilateral patchy infiltrates, and en-largement of mediastinal and hilar lymph nodes.…”
Section: Discussionmentioning
confidence: 97%
“…All cases of azacitidine-induced pulmonary toxicity have been described as pneumonitis and eosinophilic pneumonia which are characterized by cough, lung infiltrates, and the presence of eosinophils in the alveolar spaces and pulmonary interstitium [12][13][14][15][16]. Chest CT in all cases showed bilateral airspace disease, nodular opacities, bilateral patchy infiltrates, and en-largement of mediastinal and hilar lymph nodes.…”
Section: Discussionmentioning
confidence: 97%
“…Ceftriaxone + azithromycin IV 2. IV methylprednisolone 1 mg/kg twice daily Recovered NA Hayashi et al 2012; Japan [ 9 ] MDS M 74 Fever, dry cough, worsening shortness of breath 2 days Chest X-ray: infiltration in the right middle lung field Cultures negative Chest tomography: organizing pneumonia 1. Cefepime 2.…”
Section: Discussionmentioning
confidence: 99%
“…6,8,9 However, the observed clinical consequences were sufficiently serious to consider this adverse event as clinically significant. Our case report contributes to input these toxicity data.…”
Section: Discussionmentioning
confidence: 99%
“…5 Although azacitidine is well tolerated, rare clinical data from literature report interstitial lung disease secondary to azacitidine administration, which should therefore be considered as a serious potential adverse event. [6][7][8][9] We, herein, report a case of an 86-year-old white woman with AML and azacitidine-induced interstitial pneumonitis.…”
Section: Introductionmentioning
confidence: 97%