Azadirachta indica (Neem) and Berberis aristata (Indian Barberry)

Gurme, Swati T.; Patil, Devashree N.; Jadhav, Suchita V.; Ahire, Mahendra L.; Mundada, Pankaj S.

doi:10.1201/9781003205067-18

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“…Traditionally, A. indica was considered as the village pharmacy due to its broad range of medicinal applications, such as respiratory problems, rheumatism, chickenpox, jaundice, cancer, diabetes, heart ailments and gastrointestinal disorders. Many bioactive phytochemicals of A. indica, such as alkaloids, limonoids, terpenoids, reducing sugar, gallic acid, flowerone, diepoxyazadirol, catechins, sterols and flowerine (Gurme et al 2022). Studies…”

Section: Fidelity Levelmentioning

confidence: 99%

thnomedicinal and conservation evaluation of the traditional medicinal plant species employed by the Van Gujjar Tribe in the Dehradun Shivalik Hills, Uttarakhand, India Authors

Gupta

Agarwal²,

Yadav³

2023

Ethnobot. Res. App.

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Background: To the best of our knowledge, this is the first quantitative and conservation ethnomedicinal evaluation of the Van Gujjar Tribe inhabited in the Delhi-Dehradun Highway Shivalik hills Belt (DHSB). The study area is situated adjacent to biodiversity hotspot Rajaji National Park, Uttarakhand, which is an important part of Himalayan systems. The area is ecologically sensitive, increasing anthropogenic disturbance and overexploitation of medicinal herbs is also major concern. So, along with conventional ethnobotanical studies, conservation analysis of the area is important.Methods: This ethnomedicinal study comprised extensive field surveys and repetitive interviews of 120 informants of the Van Gujjar tribe with different social and educational backgrounds. Procured data were analyzed using three different quantitative indices, i.e. the relative frequency of citations (RFC), informant consensus factor (ICF), and the fidelity level (FL%). Collected plant samples were identified by relevant flora literature and online plant databases. Identified species conservation status was derived from The IUCN online database.Results: A total of 71 medicinal plant species from 67 genera and 41 families were documented from the study area. The most frequently used species, Zingiber officinale Azadirachta indica A. Juss, and Ageratum conyzoides L.were employed for multiple health issues, mainly for digestive and respiratory disorders. The highest RFC values are Z. officinale (RFC = 1.0), A. indica A. Juss. (0.99) and A. conyzoides L. (0.92. FL% of these species were 96%, 90% and 83 % viz. The highest ICF value is 0.98, which shares dental & gum problems, digestive disorders and wounds categories. The IUCN status of 71 reported medicinal plant species indicated 28.1 % plant species were least concerned, 4.2 % critically endangered (Chlorophytum borivilianum,Commiphora wightii, Nardostachys jatamansi), 1.4 % near threatened and 1.4 % endangered, 2.8 % Data Deficient, while 61.9 % species status remained unknown as currently not available in IUCN Red data list. Highly utilized species IUCN status however under 'least concerned' category.Conclusions: The study aids medicinal plant species data with current conservation status in the Delhi-Dehradun Highway Shivalik hills Belt. Medicinal plant species such as Chlorophytum borivilianum, Commiphora wightii, and Nardostachys jatamansi are critically endangered and others could be prone due to overexploitation. The present data could help to fill the previous conservation and quantitative ethnobotanical studies gaps in the study area.

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Section: Fidelity Levelmentioning

confidence: 99%

thnomedicinal and conservation evaluation of the traditional medicinal plant species employed by the Van Gujjar Tribe in the Dehradun Shivalik Hills, Uttarakhand, India Authors

Gupta

Agarwal²,

Yadav³

2023

Ethnobot. Res. App.

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“…In mice, crude ethanol extract of neem (Azadirachta indica) leaves showed a dosedependent increase in both individual (breaks and gaps) and gross (aneuploidy and polyploidy) types of abnormalities in the bone marrow cells and in its pure form, formulation, and crude extracts azadirachtin can produce ecotoxicological consequences including abnormal behaviour, physiological imbalances, and growth inhibition [32][33][34] . Gurme et al 35 reported that 28 M azadirachtin reduced the proportion of dividing cells and induced the formation of micronuclei in TP53 mutant cell lines. These results suggest that neem leaf extract and azadirachtin can be genotoxic to mammalian cells.…”

Section: Dmso-control (+) Control-cyclophosphamide P -Polychromatic C...mentioning

confidence: 99%

Untitled

2023

IJPSR

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Isolation of plant-based pesticides gaining recent interest due to the clastogenic implications of synthetic insecticides. The polyphenolic-rich fraction from the stem bark of Streblus asper was proven as an insecticide against Dysdercus cingulatus. This study aims to evaluate the genotoxicity of polyphenolic bioinsecticide from Streblus asper (PBSA) using the mouse bone marrow micronucleus assay and compare its effect with malathion, an organophosphorus insecticide, and vepacide, a neem-based bioinsecticide. The micronucleus assay was conducted after 24 and 48 hours after the second administration of the pesticides (two doses by i.p. injection for two consecutive days). Swiss albino mice were divided into six groups, each comprising six animals. The first group received dimethyl sulphoxide (Group I -DMSO control), the second group (Group II -positive control) received 100mg cyclophosphamide/ Kg body weight, Group III received 276mg (LD 10 ) malathion/ Kg body weight and Group IV received 1000mg (LD 10 ) vepacide/ Kg body weight. Group V and VI received 500 and 1000mg polyphenolic-rich fraction (PBSA)/ Kg body weight respectively. A significantly higher frequency of micronuclei was observed in malathion and vepacide administered animals when compared to the DMSO control group whereas in the case of PBSA, no significant micronuclei formation was observed. The study concluded that polyphenolic rich fraction (PBSA) fails to influence the induction of micronuclei by proving that it has no cytogenetic toxic potential.

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Azadirachta indica (Neem) and Berberis aristata (Indian Barberry)

Cited by 2 publications

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thnomedicinal and conservation evaluation of the traditional medicinal plant species employed by the Van Gujjar Tribe in the Dehradun Shivalik Hills, Uttarakhand, India Authors

thnomedicinal and conservation evaluation of the traditional medicinal plant species employed by the Van Gujjar Tribe in the Dehradun Shivalik Hills, Uttarakhand, India Authors

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