Azathioprine‐induced pure red cell aplasia in a systemic sclerosis patient with interstitial pneumonia

Suto, Mariko; Nagai, Yayoi; Hasegawa, Michiko; Handa, Hiroshi; Ishikawa, Osamu

doi:10.1111/j.1346-8138.2010.01005.x

Cited by 4 publications

(1 citation statement)

References 15 publications

(14 reference statements)

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“…Azathioprine is known to cause PRCA; because our patient had been receiving azathioprine for 4 years, we initially suspected it might be the cause of anemia. However, drug-induced PRCA remits soon after drug discontinuation [1], and azathioprine-induced PRCA has been reported only in renal transplant patients [3, 4] excluding one case [5]. Therefore, we concluded that azathioprine was an unlikely causative agent.…”

Section: Discussionmentioning

confidence: 87%

Pure red cell aplasia associated with autoimmune hepatitis successfully treated with cyclosporine A

Satô

Sano

Ishii

et al. 2014

Clin J Gastroenterol

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A 47-year-old female with a 17-year history of autoimmune hepatitis had been treated with prednisolone, azathioprine, and ursodeoxycholic acid. Although her alanine aminotransferase level occasionally showed mild abnormality, the prednisolone dose could not be increased because she had developed cataract during the course of her illness. In May 2012, she developed severe normochromic normocytic anemia without hemorrhage, and azathioprine was discontinued because it was suspected of being the cause. However, anemia recurred frequently even after discontinuation, necessitating repeated blood transfusions. Bone marrow analysis revealed selective erythroblastopenia, thus leading to a diagnosis of pure red cell aplasia. Cyclosporine A was administered, which led to a dramatic recovery from anemia, and stabilized her alanine aminotransferase levels. Furthermore, the prednisolone dose could be gradually tapered. Pure red cell aplasia associated with autoimmune hepatitis is extremely rare. The present case shows that patients with autoimmune hepatitis refractory to the standard treatment regimen and those with concomitant pure red cell aplasia may be treated with cyclosporine A.

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Section: Discussionmentioning

confidence: 87%