Azetidinium Functionalized Polytetrahydrofurans: Antimicrobial Properties in Solution and Application to Prepare Non Leaching Antimicrobial Surfaces

Abstract

Abstract:In this work, we report the antimicrobial efficacy of azetidinium functionalized polytetrahydrofurans in solution and their application in the preparation of non leaching, antimicrobial surfaces. The excellent antimicrobial efficacy of these water soluble polymers both in solution and on surfaces (>99.99%-100% bacterial growth inhibition) makes them excellent candidates for solving the hygiene related problems in the medical and hospital environment.

Synthesis and fabrication of high‐potent antimicrobial polymeric ultrathin coatings

“…1 Data analysis from U.S. Centers for Disease Control and Prevention reported that people in millions are infected with antibiotic-resistant bacteria, and thousands of them die annually due to infections in the United States. 1 Data analysis from U.S. Centers for Disease Control and Prevention reported that people in millions are infected with antibiotic-resistant bacteria, and thousands of them die annually due to infections in the United States.…”

“…5 The global market of antimicrobial coatings (AMCs) will reach $4.5 billion and nearly 590 kt of production volume by 2020, forecasted by International Antimicrobial Council, 2015. 1,5,[7][8][9] The attention is paid on the synthesis of antimicrobial reactive polymers/coatings due to their low toxicity, long-term activity, increased antimicrobial activity, high effectiveness and selectivity, stability, and also due to eco-friendly performance. ], or antibiotics); (2) contact active immobilized molecules (e.g., quaternary ammonium/chitosan polymers or peptides); or (3) light-activated molecules (e.g., TiO 2 or photosensitizers).…”

“…One of the most daunting problems of human health in today's life is deadly infections caused by pathogenic microbes. 1 Data analysis from U.S. Centers for Disease Control and Prevention reported that people in millions are infected with antibiotic-resistant bacteria, and thousands of them die annually due to infections in the United States. One of the global strategy recommendations dictated by the World Health Organization is to make the control of antimicrobial resistance a priority for National Governments and health Systems.…”

“…5 The global market of antimicrobial coatings (AMCs) will reach $4.5 billion and nearly 590 kt of production volume by 2020, forecasted by International Antimicrobial Council, 2015. 4 Various chemical strategies and technologies for AMCs are described in the literature: (1) AMCs containing active eluting agents (e.g., ions, nanoparticles [silver, copper, zinc, etc. ], or antibiotics); (2) contact active immobilized molecules (e.g., quaternary ammonium/chitosan polymers or peptides); or (3) light-activated molecules (e.g., TiO 2 or photosensitizers).…”

“…4,6 The demand is increased for the biocidal polymeric coating materials due to their capability of killing microbes upon contact. 1,5,[7][8][9] The attention is paid on the synthesis of antimicrobial reactive polymers/coatings due to their low toxicity, long-term activity, increased antimicrobial activity, high effectiveness and selectivity, stability, and also due to eco-friendly performance. 10,11 Most of AMCs describes the use of nanoparticles, natural polymers, synthetic polymers, peptides, and so on, because of exhibiting superior antimicrobial efficacy.…”