Azidotrimethylsilane

Abstract

This feature focuses on a reagent chosen by a postgraduate, highlighting the uses and preparation of the reagent in current research 1554 spotlight Azidotrimethylsilane Compiled by Bao-Le Li Bao-Le Li was born in Hengshui, Hebei Province (P. R. of China) in 1987. He graduated from the Hebei Normal University and received his B.Sc. in chemistry in 2011. Currently, he is working towards his M.Sc. degree under the supervision of Professor Zhan-Hui Zhang at the same university. His current interests are the development of new methods for the synthesis of biologically active heterocyclic compounds.

An eco‐friendly synthesis of 5‐aminotetrazoles using trichloroisocyanuric acid as desulfurization agent of thioureas

“…Therefore, the reaction of 1‐butyl‐3‐phenylthiourea ( 1a ) with trichloroisocyanuric acid (2 mol equiv) and sodium azide in the environmentally friendly ethyl acetate [30] gave N ‐butyl‐1‐phenyl‐1 H ‐tetrazol‐5‐amine ( 2a ) in only 37% yield. However, to our delight, changing the azide source to trimethylsilyl azide (TMSN 3 ), a stable, safer, and attractive azidating agent [31] resulted in a homogeneous reaction medium and 64% yield of 2a (Scheme 2).…”