2000
DOI: 10.1046/j.1365-4362.2000.00749.x
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Azithromycin for the treatment of acne

Abstract: The results show that azithromycin is a safe and effective alternative in the treatment of inflammatory acne with few side-effects and good compliance, and suggest the need for further investigation with a clinical trial that will compare the long-term efficacy and tolerability.

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Cited by 58 publications
(42 citation statements)
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“…Being a macrolide antibiotic that has recently been used successfully in several inflammatory disorders, such as acne and cutaneous rosacea, azithromycin was chosen as the study drug in this trial. 15,19,20 Moreover, it has been accepted as a promising agent because of its few side-effects, limited drug interactions and good patient compliance. 21 Its basic mechanism of action is believed to be by its anti-inflammatory properties.…”
Section: Discussionmentioning
confidence: 99%
“…Being a macrolide antibiotic that has recently been used successfully in several inflammatory disorders, such as acne and cutaneous rosacea, azithromycin was chosen as the study drug in this trial. 15,19,20 Moreover, it has been accepted as a promising agent because of its few side-effects, limited drug interactions and good patient compliance. 21 Its basic mechanism of action is believed to be by its anti-inflammatory properties.…”
Section: Discussionmentioning
confidence: 99%
“…No pharmacokinetic drug-drug interactions have been observed in trials studying the concomitant use of azithromycin and other medications (8,9). Azithromycin at a dose of 250 mg three times a week was shown to be safe and effective in the treatment of acne in an open trial by Fernandez-Obergon (10,11). Similarly, Gruber et al (12) compared azithromycin 500 mg for 4 days every 10 days with minocycline.…”
Section: Discussionmentioning
confidence: 99%
“…Due to its improved pharmacokinetic properties, high tolerability profile and high susceptibility of propionibacterium acnes to azithromycin, 3 the rationale for the use of azithromycin in acne has been examined and it has been found to be effective in a few clinical studies. [4][5][6] Tetracyclines are the first-line antiacne antibiotics. 7 However tetracyclines may be associated with a fairly large number of adverse effects mucocutaneous (photosensitivity, pigmentation of skin and nails, Gramnegative folliculitis, contact hypersensitivity, fixed drug eruptions, oral and vaginal candidiasis, systemic lupus erythematosus, that way the, psoriasis exacerbation) or systemic (antianabolic effects, nausea, vomiting, diarrohea, esophageal irritation and ulceration, Fanconi syndrome, acute interstitial nephritis, vertigo, vestibular disturbance, benign intracranial hypertension, severe hypersensitivity reactions, megaloblastic anaemia and thrombocytopenic purpura).…”
Section: Introductionmentioning
confidence: 99%