“…Due to its improved pharmacokinetic properties, high tolerability profile and high susceptibility of propionibacterium acnes to azithromycin, 3 the rationale for the use of azithromycin in acne has been examined and it has been found to be effective in a few clinical studies. [4][5][6] Tetracyclines are the first-line antiacne antibiotics. 7 However tetracyclines may be associated with a fairly large number of adverse effects mucocutaneous (photosensitivity, pigmentation of skin and nails, Gramnegative folliculitis, contact hypersensitivity, fixed drug eruptions, oral and vaginal candidiasis, systemic lupus erythematosus, that way the, psoriasis exacerbation) or systemic (antianabolic effects, nausea, vomiting, diarrohea, esophageal irritation and ulceration, Fanconi syndrome, acute interstitial nephritis, vertigo, vestibular disturbance, benign intracranial hypertension, severe hypersensitivity reactions, megaloblastic anaemia and thrombocytopenic purpura).…”