Azithromycin-loaded respirable microparticles for targeted pulmonary delivery for the treatment of pneumonia

Wang, Qiyue; Mi, Gujie; Hickey, Daniel; Li, Yanan; Tu, Jiasheng; Webster, Thomas J.; Shen, Yan

doi:10.1016/j.biomaterials.2018.01.022

Cited by 46 publications

(32 citation statements)

References 50 publications

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“…Although the occurrence rate of Reduning injection combined with azithromycin was higher than others, no studies have shown Reduning injection can cause liver dysfunction. On the other hand, azithromycin was metabolized by liver and kidney following intravenous injection and oral medication, so long‐term medication can lead to abnormal liver function. Hence, in the treatment of mycoplasma pneumonia in children with azithromycin, whether or not combined with injection, we should not only pay attention to gastrointestinal reactions, but also pay special attention to the liver function of patients.…”

Section: Discussionmentioning

confidence: 99%

“…Azithromycin, a broad‐spectrum antibacterial and second‐generation macrolide, could inhibit bacterial protein synthesis, quorum sensing and reduces the formation of biofilm . It has longer half‐life and cellular targeting, and is used to reduce respiratory and other bacterial infections, such as gram‐positive, gram‐negative and atypical bacterial infections that lead to pneumonia . Azithromycin is a first‐line outpatient treatment in the case of bacterial pneumonia in the United States, or as part of a combination therapy in patients who require hospitalization .…”

Section: Discussionmentioning

confidence: 99%

“…It has longer half‐life and cellular targeting, and is used to reduce respiratory and other bacterial infections, such as gram‐positive, gram‐negative and atypical bacterial infections that lead to pneumonia . Azithromycin is a first‐line outpatient treatment in the case of bacterial pneumonia in the United States, or as part of a combination therapy in patients who require hospitalization . In addition, azithromycin is often used to treat mycoplasma pneumonia in children in China.…”

Section: Discussionmentioning

confidence: 99%

“…36 It has longer half-life and cellular targeting, and is used to reduce respiratory and other bacterial infections, such as gram-positive, gram-negative and atypical bacterial infections that lead to pneumonia. 10,35,37 Azithromycin is a first-line outpatient treatment in the case of bacterial pneumonia in the United…”

Section: Discussionmentioning

confidence: 99%

“…Interventions with the same colour belonged to the same cluster, and interventions located in the upper right corner indicate optimal therapy for two different outcomes F I G U R E 6 Comparison-adjusted funnel plot for the rate of clinical efficacy.Points with different colours represent different interventions. If the points distributed in the funnel are symmetrical, there is no publication bias States, or as part of a combination therapy in patients who require hospitalization 35,38. In addition, azithromycin is often used to treat mycoplasma pneumonia in children in China.…”

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confidence: 99%

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Comparative efficacy of Chinese herbal injections combined with azithromycin for mycoplasma pneumonia in children: A Bayesian network meta‐analysis of randomized controlled trials

Duan

Wang

et al. 2019

J Clin Pharm Ther

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What is known and objectiveAn increasing macrolide resistance leads to complex clinical treatment schemes in mycoplasma pneumonia in children. Chinese herbal injection (CHI) is widely used to treat it and may provide a new treatment regimen. This study was conducted to systematically evaluate the efficacy of CHIs combined with azithromycin for treating mycoplasma pneumonia in children by Bayesian network meta‐analysis.MethodsRandomized controlled trials (RCTs) of CHIs combined with azithromycin for mycoplasma pneumonia in children were searched in electronic databases and related references from initiation to 30 October 2018. Two researchers conducted data extraction and risk of bias assessment. WinBUGS software and STATA software were adopted to analyse the data.ResultsA total of 167 RCTs were included with 5 CHIs involving 16 144 patients. All CHIs combined with azithromycin had superior effects than azithromycin only among overall outcomes. Yanhuning injection combined with azithromycin ranked highest in four different outcomes and second in two based on surface under the cumulative ranking probabilities (SUCRA). Meanwhile, the results of MD and 95% CIs of concerned outcomes indicated that only Yanhuning injection combined with azithromycin had better response than other CHIs combined with azithromycin. Moreover, cluster analysis results revealed Reduning injection combined with azithromycin was associated with a positive effect on the three group outcomes. Similarly, it was found to be the top three ranking in all outcomes based on SUCRA.What is new and conclusionYanhuning injection combined with azithromycin and Reduning injection combined with azithromycin were found to be preferable treatments based on the data of this study.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Comparative efficacy of Chinese herbal injections combined with azithromycin for mycoplasma pneumonia in children: A Bayesian network meta‐analysis of randomized controlled trials

Duan

Wang

et al. 2019

J Clin Pharm Ther

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“Cluster Bomb” Based Bismuth Nano‐in‐Micro Spheres Formed Dry Powder Inhalation for Thermo‐Radio Sensitization Effects of Lung Metastatic Breast Cancer

Wang

Chen

Miao

et al. 2023

Adv Healthcare Materials

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Lung metastatic breast cancer (LMBC) is mainly diagnosed through CT imaging and radiotherapy could be the most common method in the clinic to inhibit tumor proliferation. While the sensitivity of radiotherapy is always limited due to the hypoxic tumor microenvironment and high doses of irradiation easily induce systemic cytotoxicity. Metal‐based materials applied as radiosensitizers have been widely investigated to improve efficiency and reduce the doses of irradiation. Herein, it is aimed to overcome these problems by designing biodegradable lipid‐camouflaged bismuth‐based nanoflowers (DP‐BNFs) as both a photo‐thermo‐radiosensitizer to develop a novel photothermal therapy (PTT) and radiotherapy combination strategy for LMBC treatment. To achieve effective lung deposition, “Cluster Bomb” structure‐based DP‐BNFs nano‐in‐micro dry powder inhalation (DP‐BNF@Lat‐MPs) are formulated through spray‐dried technology. The DP‐BNFs “cluster” in the microsphere to improve their tumor‐targeted lung deposition with a high fine particle fraction followed by burst releasing of DP‐BNFs for targeting delivery and LMBC therapy. The DP‐BNF@Lat‐MPs exhibit excellent photothermal conversion efficiency, radiotherapy enhancement, and CT imaging ability in vitro, which synergistically inhibit cell proliferation and metastasis. In vitro and in vivo data prove that combining PTT and radiotherapy with DP‐BNF@Lat‐MPs as a thermo‐radio dual‐sensitizer significantly enhances LMBC tumor metastasis inhibition with good biocompatibility and low toxicity.

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A Biomimetic Non‐Antibiotic Approach to Eradicate Drug‐Resistant Infections

et al. 2018

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The chronic infections by pathogenic Pseudomonas aeruginosa (P. aeruginosa) remain to be properly addressed. In particular, for drug‐resistant strains, limited medication is available. An in vivo pneumonia model induced by a clinically isolated aminoglycoside resistant strain of P. aeruginosa is developed. Tobramycin clinically treating P. aeruginosa infections is found to be ineffective to inhibit or eliminate this drug‐resistant strain. Here, a newly developed non‐antibiotics based nanoformulation plus near‐infrared (NIR) photothermal treatment shows a remarkable antibacterial efficacy in treating this drug‐resistant pneumonia. The novel formulation contains 50–100 nm long nanorods decorated with two types of glycomimetic polymers to specifically block bacterial LecA and LecB lectins, respectively, which are essential for bacterial biofilm development. Such a 3D display of heteromultivalent glycomimetics on a large scale is inspired by the natural strengthening mechanism for the carbohydrate–lectin interaction that occurs when bacteria initially infects the host. This novel formulation shows the most efficient bacteria inhabitation and killing against P. aeruginosa infection, through lectin blocking and the near‐infrared‐light‐induced photothermal effect of gold nanorods, respectively. Collectively, the novel biomimetic design combined with the photothermal killing capability is expected to be an alternative treatment strategy against the ever‐threatening drug‐resistant infectious diseases when known antibiotics have failed.

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Azithromycin-loaded respirable microparticles for targeted pulmonary delivery for the treatment of pneumonia

Cited by 46 publications

References 50 publications

Comparative efficacy of Chinese herbal injections combined with azithromycin for mycoplasma pneumonia in children: A Bayesian network meta‐analysis of randomized controlled trials

Comparative efficacy of Chinese herbal injections combined with azithromycin for mycoplasma pneumonia in children: A Bayesian network meta‐analysis of randomized controlled trials

“Cluster Bomb” Based Bismuth Nano‐in‐Micro Spheres Formed Dry Powder Inhalation for Thermo‐Radio Sensitization Effects of Lung Metastatic Breast Cancer

A Biomimetic Non‐Antibiotic Approach to Eradicate Drug‐Resistant Infections

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