Azithromycin therapy in infants hospitalized for respiratory syncytial virus bronchiolitis

Beigelman, Avraham; Goss, Charles W.; Wang, Jinli; Srinivasan, Mythili; Boomer, Jonathan; Zhou, Yanjiao; Bram, Sarah; Casper, Timothy J.; Coverstone, Andrea M.; Kanchongkittiphon, Watcharoot; Kuklinski, Cadence; Storch, Gregory A.; Schechtman, Kenneth B.; Castro, Mario; Bacharier, Leonard B.

doi:10.1016/j.anai.2024.01.001

Annals of Allergy, Asthma & Immunology

2024

DOI: 10.1016/j.anai.2024.01.001

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Azithromycin therapy in infants hospitalized for respiratory syncytial virus bronchiolitis

Avraham Beigelman,

Charles W. Goss,

Jinli Wang

et al.

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2024

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Cited by 2 publications

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Repositioning of Antibiotics in the Treatment of Viral Infections

Bustos-Hamdan,

Bracho-Gallardo,

Hamdan-Partida

et al. 2024

Curr Microbiol

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Drug repurposing, also known as drug repositioning, is a currently tested approach by which new uses are being assigned for already tested drugs. In this case there are antibiotics that are used to combat bacterial infections. However, antibiotics are among the drugs that have been studied for possible antiviral activities. Therefore, the aim of this work is to carry out a review of the studies of antibiotics that could be repositioned for the treatment of viral infections. Among the main antibiotics that have demonstrated antiviral activity are macrolides and glycopeptides. In addition, several antibiotics from the group of tetracyclines, fluoroquinolones, cephalosporins and aminoglycosides have also been studied for their antiviral activity. These antibiotics have demonstrated antiviral activity against both RNA and DNA viruses, including the recent pandemic virus SARS-CoV-2. Some of these antibiotics were selected in addition to its antiviral activity for their immunomodulatory and anti-inflammatory properties. Of the antibiotics that present antiviral activity, in many cases the mechanisms of action are not exactly known. The use of these antibiotics to combat viral infections remains controversial and is not generally accepted, since clinical trials are required to prove its effectiveness. Therefore, there is currently no antibiotic approved as antiviral therapy. Hence is necessary to present the studies carried out on antibiotics that can be repositioned in the future as antiviral drugs.

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Repositioning of Antibiotics in the Treatment of Viral Infections

Bustos-Hamdan,

Bracho-Gallardo,

Hamdan-Partida

et al. 2024

Curr Microbiol

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Decoding viral infections and risk for asthma

Kloepfer,

Kennedy

2024

Annals of Allergy, Asthma & Immunology

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Azithromycin therapy in infants hospitalized for respiratory syncytial virus bronchiolitis

Cited by 2 publications

References 20 publications

Repositioning of Antibiotics in the Treatment of Viral Infections

Repositioning of Antibiotics in the Treatment of Viral Infections

Decoding viral infections and risk for asthma

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