Azo-azomethine complex activity and sensor potential toward Ca(II) ion in life samples: The spectroscopic and morphological studies

Synthesis, Characterization, and Evaluation of Tetrazole Derivatives with Pyrrole‐2,5‐Dione Moieties as Urease Inhibitors: Exploring Structure‐Activity Relationships and Computational Insights

“…Frontier molecular orbitals, comprising the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO), are crucial for revealing a molecule's chemical reactivity and kinetic stability. [10,15,55] The HOMO, being the highest energy orbital occupied by electrons, governs electron donation during chemical reactions, while the LUMO, as the lowest unoccupied orbital, signifies the region poised to accept electrons, indicating the molecule's propensity for electron acceptance. Electronic absorption, a fundamental concept, describes the transition of electrons from the ground state to the first excited state.…”

“…Heterocyclic compounds, particularly those containing nitrogen, constitute a significant class of organic molecules renowned for their diverse biological activities and pharmaceutical importance. [7][8][9][10] Nitrogen-containing heterocycles are ubiquitous in nature and play pivotal roles in numerous biological processes, including enzyme catalysis, [11,12] signal transduction, [13][14][15] and molecular recognition. Their structural versatility allows for the modulation of various biological targets, making them valuable scaffolds in drug discovery and development.…”

A synergistic investigation of azo-thiazole derivatives incorporating thiazole moieties: a comprehensive exploration of their synthesis, characterization, computational insights, solvatochromism, and multimodal biological activity assessment

“…21,22 Azo-thiazole refers to a class of organic compounds that contain both an azo group (N]N) and a thiazole ring in their molecular structure. 23 This unique combination of functional groups contributes to the distinct properties and potential applications of this compound in various elds. However, although heterocyclic compounds containing azo groups have a substantial presence in pharmaceuticals and the development of therapeutic agents, the related literature remains somewhat limited.…”