1978
DOI: 10.1073/pnas.75.9.4524
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Azo dyes prevent hydrocarbon-induced leukemia in the rat.

Abstract: A set of intravenous injections of 7,8,12-tri- In the experiments now to be described it was found that a set of multiple intravenous injections of 7,8,8, at biweekly intervals consistently elicited leukemia in adult female Long-Evans rats in more than 75% of the animals at risk within 8 weeks. Thus, we have produced hydrocarbon-induced leukemogenesis at a high frequency in these rats. In the present work it was found that a single feeding of a small quantity (1 mg) of certain azo dyes prior to the intravenous… Show more

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Cited by 29 publications
(11 citation statements)
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“…The experiment was conducted as described for Fig. 2 (26,31,32). A number of azo dyes resemble polycyclic aromatic hydrocarbons in inducing both phase I enzymes (cytochrome P-448-dependent monooxygenases) and phase II enzymes (quinone reductase, UDPglucuronyltransferase, glutathione S-transferase, and aldehyde dehydrogenase) (11,12 (19) resulted in 4-to 12-fold inductions of quinone reductase (ref.…”
Section: Resultsmentioning
confidence: 99%
“…The experiment was conducted as described for Fig. 2 (26,31,32). A number of azo dyes resemble polycyclic aromatic hydrocarbons in inducing both phase I enzymes (cytochrome P-448-dependent monooxygenases) and phase II enzymes (quinone reductase, UDPglucuronyltransferase, glutathione S-transferase, and aldehyde dehydrogenase) (11,12 (19) resulted in 4-to 12-fold inductions of quinone reductase (ref.…”
Section: Resultsmentioning
confidence: 99%
“…NQO1 prevents the generation of semiquinone free radical and reactive oxygen species, then protecting cells from oxidative damage (Rauth et al 1997). Furthermore, this enzymatic activity is believed to protect cells from mutagenesis (Chesis et al 1984) and carcinogenesis (Huggins et al 1978;Traver et al 1997). The direct evidence that AD patients have increased NQO1 activity had been provided (Raina et al 1999;Wang et al 2000).…”
Section: Introductionmentioning
confidence: 98%
“…DT-diaphorase is an inducible enzyme (16) that may protect the cell from oxidative damage by preventing oxyradical formation from one-electron reduction of quinones and the subsequent formation of superoxide radicals via dismutation of the semiquinone (17,18). Its protective capacitywith respect to quinone carcinogenesis has been demonstrated (19,20), and it has been labeled an "anticancer enzyme" (21).…”
mentioning
confidence: 99%