Abstract:Systemic fungal diseases and antifungal resistance represent a serious problem in human medicine and contribute to increased patient mortality. The most common causes of these diseases are opportunistic yeasts of the genus Candida. C. albicans is considered to be the main pathogen, together with C. glabrata, C. tropicalis, C. parapsilosis, and C. krusei. Azole antifungals predominate in the treatment of the systemic mycoses. For antifungal resistance in Candida spp. some genes and their mutations are responsib… Show more
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