Azoles and <i>bis</i>-Azoles: Synthesis and Biological Evaluation as Antimicrobial and Anti-cancer Agents

A review on bis-hydrazonoyl halides: Recent advances in their synthesis and their diverse synthetic applications leading to bis-heterocycles of biological interest

“…Similarly, the coupling of 3-chloro-2,4-pentanedione 7 with diazonium chloride of benzidine 6 in ethanol, in the presence of sodium acetate afforded N ′, N ″-(biphenyl-4,4′-diyl)- bis (2-oxopropanehydrazonoyl chloride) VI ( Scheme 10 ). The results of evaluating the anticancer activity of VI against colon carcinoma (HCT) revealed that it has moderate activity [37] .…”

Regioselective Synthesis of Some Pyrazole Scaffolds Attached to Benzothiazole and Benzimidazole Moieties

“…For example, 2-amino-3-aroylthiophene derivatives are reported as agonist allosteric enhancers at the A1 adenosine receptor [22,23]. In view of the abovementioned findings and in continuation of our previous work aimed at the synthesis of a variety of heterocyclic ring systems for biological and pharmacological evaluation [24][25][26][27][28][29], we report here an efficient method for the synthesis of some pyrazole derivatives attached to benzothiazole and benzimidazole moieties.…”

Synthesis and Antimicrobial Activities Evaluation of New Spiro[4.5]dec-2-enes Containing 1,2,4-Triazole, Piperidine and Sulfonamide Moieties

“…A survey of the literature has shown that compounds having azole derivatives to possess diverse biological activity and are widely used in a medicinal chemistry [15][16][17][18]. The 1,2,4-triazole derivatives has received a considerable attention in view of their diverse pharmacological activities [19][20][21][22] such as antimicrobial [23,24] sedative, anticonvulsant [25], anti-inflammatory properties [26] and anticancer agents.…”