Azotaemia Aggravated by Tetracycline

Edwards, O. M.; Huskisson, E. C.; Taylor, Ruth

doi:10.1136/bmj.1.5687.26

Cited by 27 publications

(5 citation statements)

References 10 publications

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“…Her infection responded well to tetracycline, the recommended first-line treatment. Some authorities recommend that tetracycline should not be used in patients with impaired renal function, because it may cause an increased concentration of BUN due to an antianabolic and diuretic effect [19,20]. Moreover, impaired excretion results in increased tetracycline accumulation and potential toxicity [21].…”

Section: Discussionmentioning

confidence: 99%

Urinary balantidiasis in a patient with systemic lupus erythematosus and lupus nephritis: a case report

et al. 2020

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Background Balantidium coli, a parasitic unicellular ciliate, often causes asymptomatic balantidiasis of the colon, but extraintestinal disease may occur rarely in immunosuppressed individuals. Renal balantidiasis associated with systemic lupus erythematosus has not been reported before. Case presentation We present a case of a 48-year-old Thai woman who presented with nephrotic syndrome due to systemic lupus erythematosus–related nephritis. Initially, few B. coli cysts were found in urine sediment, but these increased substantially following treatment with prednisolone. She made an uneventful recovery with 10 days of oral tetracycline therapy. No B. coli cysts were found in her stool. Conclusion The route of infection in our patient was unclear but is likely to have been orofecal. Neither her infection nor its treatment caused a deterioration in her renal function.

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Section: Discussionmentioning

confidence: 99%

Urinary balantidiasis in a patient with systemic lupus erythematosus and lupus nephritis: a case report

et al. 2020

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“…Tetracyclines should be avoided in the treatment of patients with renal failure. They increase protein breakdown, and can induce a severe worsening in the uraemic state (Edwards, Huskisson and Taylor, 1970).…”

Section: Eradication Of Infectionmentioning

confidence: 99%

The Clinical Features, Complications and Treatment of Chronic Renal Failure

Petrie

1972

British Journal of Anaesthesia

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The kidneys are responsible for the excretion of nitrogenous waste products and the elimination of the non-volatile acids produced by metabolism. Through selective reabsorption of the bulk of the glomerular filtrate, they regulate the volume and composition of the body fluids. Because of the part they play in the control of sodium balance and in the production of the enzyme renin, they are intimately concerned in the regulation of blood pressure. As the main source of the hormone erythropoetin, they are essential to normal red blood cell production. In view of the variety and importance of the tasks performed by the kidneys, it is not surprising that when renal failure supervenes the effects are manifest in practically every system of the body.

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“…Tetracycline depresses the protein metabolism of mammalian cells (Edwards, Huskisson, and Taylor, 1970), and neomycin, at least in large doses, can itself induce malabsorption (Dobbins, Herrero, and Mansbach, 1968). Nevertheless the remarkable responses to antibacterial therapy sometimes obtained, together with other evidence from quantitative studies of the upper gut flora, provide us with reasons for believing that man's intestinal microflora may influence his state of health sometimes to his benefit, more often (or at least more often recognized) to his detriment.…”

Section: Effect Of Antibioticsmentioning

confidence: 99%