B-74 * The Relationship of Myelin Content and Measures of Executive Functioning in Typically Developing Children

High‐resolution quantitative MRI of multiple sclerosis spinal cord lesions

“…In contrast, gradient echo–based methods, such as the driven equilibrium single‐pulse observation of T 1 and T 2 , are inherently fast 22 . A multi‐component version of driven equilibrium steady‐state observation of T 1 and T 2 (mcDESPOT) has been used in clinical studies of MS, 23 primary lateral sclerosis, 24 and monitoring myelin development in children 25–29 . However, histological validation has been lacking, and recent work has shown that mcDESPOT suffers from unpredictable bias, but as there was sufficient data for analysis, we present it here 30,31 …”

“…22 A multi-component version of driven equilibrium steady-state observation of T 1 and T 2 (mcDES-POT) has been used in clinical studies of MS, 23 primary lateral sclerosis, 24 and monitoring myelin development in children. [25][26][27][28][29] However, histological validation has been lacking, and recent work has shown that mcDESPOT suffers from unpredictable bias, but as there was sufficient data for analysis, we present it here. 30,31 Given that significant efforts in MS research are directed toward development of strategies for myelin repair (remyelination), 32 imaging biomarkers of myelin are desirable.…”