B.8 - Tryptophan Depletion Diet in Low Versus High Compulsive Drinker Rats Selected by Schedule-Induced Polydipsia

Merchán, Ana; Navarro, Silvia; Sánchez-García, Sergio; Moreno, Margarita; Flores, Pilar

doi:10.1097/01.fbp.0000434780.18559.cb

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“…Lister Hooded compared to Wistar rats typically displayed higher levels of exploratory behavior and lower levels of anxiety [36] [37]. Wistar rats more readily acquired SIP and exhibited a greater level of water drinking than Lister Hooded [38] [39]. Moreover, the SIP task has proved to be sensitive to genotypic differences in alcohol consumption, revealing that strain differences in a SIP alcohol drinking paradigm between C57BL/6J and DBA/2J mice are the same as those obtained using more traditional methods of alcohol self-administration [10].…”

Section: Genetic Differences: Are Rat Strains Different In Sip Acquismentioning

confidence: 96%

Schedule-Induced Polydipsia: Searching for the Endophenotype of Compulsive Behavior

Flores¹,

Sánchez-Kuhn²,

Merchán³

et al. 2014

WJNS

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The development of excessive and persistent drinking under intermittent food-reinforcement schedules, known Schedule-induced polydipsia (SIP), has been proposed as a successful animal model to study compulsive behaviors. On the last decade, we have been working in our laboratory on the stratification of the compulsive rats on SIP in order to know whether differences in the acquisition of compulsive drinking behavior could predict alterations in other behavioral measures as well as in the neurochemical function typically associated with compulsive spectrum disorders. The aim of this review is to collate the main findings relevant to the characterization and use of the high compulsive drinking rats (HD) in SIP as a possible compulsive endophenotype. The review of the genetic, behavioral and neurochemical differences found in the selection allows us to conclude that HD rats could be a valid model for studying the compulsive phenotype and modelling psychopathology common to a variety of compulsivity spectrum disorders such as obsessivecompulsive disorder (OCD), schizophrenia and alcohol abuse.

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Section: Genetic Differences: Are Rat Strains Different In Sip Acquismentioning

confidence: 96%

Schedule-Induced Polydipsia: Searching for the Endophenotype of Compulsive Behavior

Flores¹,

Sánchez-Kuhn²,

Merchán³

et al. 2014

WJNS

Self Cite

View full text Add to dashboard Cite

show abstract

B.8 - Tryptophan Depletion Diet in Low Versus High Compulsive Drinker Rats Selected by Schedule-Induced Polydipsia

Cited by 1 publication

References 0 publications

Schedule-Induced Polydipsia: Searching for the Endophenotype of Compulsive Behavior

Schedule-Induced Polydipsia: Searching for the Endophenotype of Compulsive Behavior

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