B. Alcaligenes Faecalis Septicemia In the Newborn

Khetarpal, Siddharth K.

doi:10.1177/000992286400300211

Cited by 10 publications

(4 citation statements)

References 7 publications

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“…According to the literature, there were 130 sporadically reported cases of A. faecalis infection (Table 7) [1, 2, 7-28, [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46]. The most commonly reported cases involved bacteremia, and most cases occurred in newborns and infants.…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

Extensively drug-resistant Alcaligenes faecalis infection

Huang¹

2020

BMC Infect Dis

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Background Alcaligenes faecalis is usually causes opportunistic infections in humans. Alcaligenes faecalis infection is often difficult to treat due to its increased resistance to several antibiotics. The results from a clinical study of patients with Alcaligenes faecalis infection may help improve patients’ clinical care. Methods We conducted a retrospective analysis of all patients presenting with Alcaligenes faecalis infection from January 2014 to December 2019. The medical records of all patients were reviewed for demographic information, clinical symptoms and signs, comorbidities, use of intravenous antibiotics within the past three months, bacterial culture, antibiotics sensitivity test, and clinical outcomes. Results Sixty-one cases of Alcaligenes faecalis infection were seen during the study period, including 25 cases of cystitis, nine cases of diabetic foot infection, eight cases of pneumonia, seven cases of acute pyelonephritis, three cases of bacteremia, and nine cases of infection at specific sites. Thirty-seven patients (60.7%) had a history of receiving intravenous antibiotics within three months of the diagnosis. Fifty-one (83.6%) cases were mixed with other bacterial infections. Extensively drug-resistant infections have been reported since 2018. The best sensitivity rate to Alcaligenes faecalis was 66.7% for three antibiotics (imipenem, meropenem, and ceftazidime) in 2019. Two antibiotics (ciprofloxacin and piperacillin/tazobactam) sensitivity rates to A. faecalis were less than 50%. Conclusions The most frequent Alcaligenes faecalis infection sites, in order, are the bloodstream, urinary tract, skin and soft tissue, and middle ear. The susceptibility rate of Alcaligenes faecalis to commonly used antibiotics is decreasing. Extensively drug-resistant Alcaligenes faecalis infections have emerged.

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Section: Discussion and Literature Reviewmentioning

confidence: 99%

Extensively drug-resistant Alcaligenes faecalis infection

Huang¹

2020

BMC Infect Dis

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“…To our knowledge, there were 130 sporadically reported cases of A. faecalis infection in the literature (table 7) [1,2,[31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46]. The most commonly reported cases involved bacteremia, and most cases occurred in newborns and infants.…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

Extensively drug-resistant Alcaligenes faecalis infection

Huang

2020

Preprint

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Background: Alcaligenes faecalis is usually opportunistic infection in humans. Alcaligenes faecalis infection is often challenging to treat due to its increased resistance to many antibiotics. The results from a clinical study of Alcaligenes faecalis infection may help improve patients’ clinical care. Methods: We conducted a retrospective analysis of all patients presenting with Alcaligenes faecalis infection from January 2014 through December 2019. The medical records of all patients were reviewed for demographic information, clinical symptoms and signs, comorbidities, use of intravenous antibiotics within the past 3 months, bacterial culture, antibiotics sensitivity test, and clinical outcomes. Results: Sixty-one cases of Alcaligenes faecalis infection were seen during the study period, including 25 cases of cystitis, 9 cases of diabetic foot ulcer with infection, 8 cases of pneumonia, 7 cases of acute pyelonephritis, 3 cases of bacteremia, 9 cases of infection at specific sites. Thirty-seven patients (60.7%) had a history of receiving intravenous antibiotics within 3 months of the diagnosis. Fifty-one (83.6%) cases were mixed with other bacterial infections. Extensively drug-resistant infections have been reported since 2018. The best sensitivity rate to A. faecalis was 66.7% for three antibiotics (imipenem, meropenem, and ceftazidime) in 2019. Two antibiotics (ciprofloxacin and piperacillin/tazobactam) sensitivity rates to A. faecalis were less than 50%. Conclusions: The most frequent Alcaligenes faecalis infection sites were in the bloodstream, urinary tract, skin and soft tissue, and middle ear. Alcaligenes faecalis showed markedly decreased sensitivity to commonly used antibiotics and, more recently, extensively drug-resistant Alcaligenes faecalis infections have emerged.

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“…Sixty-two A. faecalis infection cases were sporadically reported in the medical literature before 1997 (Table 7) [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43]. The most commonly reported cases involved bacteremia and meningitis, and most cases occurred in newborns and infants.…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

Extensively drug-resistant Alcaligenes faecalis infection

Huang¹

2020

Preprint

View full text Add to dashboard Cite

Background: Alcaligenes faecalis is usually opportunistic infection in humans. Alcaligenes faecalis infection is often challenging to treat due to its increased resistance to many antibiotics. The results from a clinical study of Alcaligenes faecalis infection may help improve patients’ clinical care. Methods: We conducted a retrospective analysis of all patients presenting with Alcaligenes faecalis infection from January 2014 through December 2019. The medical records of all patients were reviewed for demographic information, clinical symptoms and signs, comorbidities, use of intravenous antibiotics within the past 3 months, bacterial culture, antibiotics sensitivity test, and clinical outcomes.Results: Sixty-one cases of Alcaligenes faecalis infection were seen during the study period, including 25 cases of cystitis, 9 cases of diabetic foot ulcer with infection, 8 cases of pneumonia, 7 cases of acute pyelonephritis, 3 cases of bacteremia, 9 cases of infection at specific sites. Thirty-seven patients (60.7%) had a history of receiving intravenous antibiotics within 3 months of the diagnosis. Fifty-one (83.6%) cases were mixed with other bacterial infections. Extensively drug-resistant infections have been reported since 2018. The highest antibiotic sensitivity rate for Alcaligenes faecalis, 66.7%, was reported in 2019. Ciprofloxacin and piperacillin/tazobactam are not good choices for empiric therapy of Alcaligenes faecalis infection. Conclusions: The most frequent Alcaligenes faecalis infection sites were in the urinary tract, skin and soft tissue, and lung. Alcaligenes faecalis showed markedly decreased sensitivity to commonly used antibiotics and, more recently, extensively drug-resistant Alcaligenes faecalis infections have emerged.

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B. Alcaligenes Faecalis Septicemia In the Newborn

Cited by 10 publications

References 7 publications

Extensively drug-resistant Alcaligenes faecalis infection

Extensively drug-resistant Alcaligenes faecalis infection

Extensively drug-resistant Alcaligenes faecalis infection

Extensively drug-resistant Alcaligenes faecalis infection

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