Ambulatory blood pressure profiles and plasminogen activator inhibitor (PAI‐1) activity in lean women with and without the polycystic ovary syndrome

Abstract

The only measurable vascular risk factor associated with hyperinsulinaemia and menstrual disturbance in non-obese women with PCOS is an elevated plasma PAI-1 activity. These women did not differ from controls in ambulatory blood pressure profiles, lipid measurements or in a parental history of premature vascular disease. PAI-1 and plasminogen are involved in ovarian follicle maturation and the present finding suggests a biologically plausible link between hyperinsulinaemia, anovulation and vascular risk in PCOS.

The prevalence of 4G5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene in polycystic ovarian syndrome and its association with plasma PAI-1 levels

“…Subsequently, plasma PAI-1 levels of PCOS phenotypic group were statistically higher than those of controls Table 4 The percentages of PCOS patients and controls in genotypes 4G/4G, 4G/5G and 5G/5G. (Table 6), which is in accordance with previous studies (8,9). In this study, women with PCOS with 4G/4G genotype had higher PAI-1 levels than any other genotype in the studied groups except for 4G/4G of the control group (Table 6).…”

Plasma plasminogen activator inhibitor-1 levels in the different phenotypes of the polycystic ovary syndrome

“…In contrast, others reported higher PAI-1 levels in normal weight women with PCOS and a correlation between PAI-1 levels and both serum insulin levels and the HOMA-IR index [13,21,22]. However, our findings do not suggest that IR modulates PAI-1 levels in normal weight women with PCOS because PAI-1 levels drogenemia in the regulation of PAI-1 levels in PCOS.…”

Subcutaneous adipocytes from obese hyperinsulinemic women with polycystic ovary syndrome exhibit normal insulin sensitivity but reduced maximal insulin responsiveness

“…Studies controlling for insulin resistance have found that low high-density lipoprotein (HDL) and high triacylglycerol levels are associated with insulin resistance rather than with PCOS (10). Hypertension, furthermore, is uncommon in women with PCOS (11,12).…”