B.C.G. Vaccination and Leukæmia Mortality

Davignon, L; Lemonde, P; Pierre, J.-F. St.; Frappier, Armand

doi:10.1016/s0140-6736(71)90804-x

Cited by 32 publications

(17 citation statements)

References 6 publications

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“…Before its computerization in 2010, the Québec BCG Registry had been used in research on tuberculosis [13,16,17], leukaemia [18,19], type 1 diabetes [20], and asthma [21]. Although data from this registry can be useful in various epidemiological study designs, their most efficient utilization will be through linkage with existing provincial medical administrative health databases.…”

Section: Discussionmentioning

confidence: 99%

The Québec BCG Vaccination Registry (1956–1992): assessing data quality and linkage with administrative health databases

Rousseau

Conus

et al. 2014

BMC Med Inform Decis Mak

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BackgroundVaccination registries have undoubtedly proven useful for estimating vaccination coverage as well as examining vaccine safety and effectiveness. However, their use for population health research is often limited. The Bacillus Calmette-Guérin (BCG) Vaccination Registry for the Canadian province of Québec comprises some 4 million vaccination records (1926-1992). This registry represents a unique opportunity to study potential associations between BCG vaccination and various health outcomes. So far, such studies have been hampered by the absence of a computerized version of the registry. We determined the completeness and accuracy of the recently computerized BCG Vaccination Registry, as well as examined its linkability with demographic and administrative medical databases.MethodsTwo systematically selected verification samples, each representing ~0.1% of the registry, were used to ascertain accuracy and completeness of the electronic BCG Vaccination Registry. Agreement between the paper [listings (n = 4,987 records) and vaccination certificates (n = 4,709 records)] and electronic formats was determined along several nominal and BCG-related variables. Linkage feasibility with the Birth Registry (probabilistic approach) and provincial Healthcare Registration File (deterministic approach) was examined using nominal identifiers for a random sample of 3,500 individuals born from 1961 to 1974 and BCG vaccinated between 1970 and 1974.ResultsExact agreement was observed for 99.6% and 81.5% of records upon comparing, respectively, the paper listings and vaccination certificates to their corresponding computerized records. The proportion of successful linkage was 77% with the Birth Registry, 70% with the Healthcare Registration File, 57% with both, and varied by birth year.ConclusionsComputerization of this Registry yielded excellent results. The registry was complete and accurate, and linkage with administrative databases was highly feasible. This study represents the first step towards assembling large scale population-based epidemiological studies which will enable filling important knowledge gaps on the potential health effects of early life non-specific stimulation of the immune function, as resulting from BCG vaccination.

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Section: Discussionmentioning

confidence: 99%

The Québec BCG Vaccination Registry (1956–1992): assessing data quality and linkage with administrative health databases

Rousseau

Conus

et al. 2014

BMC Med Inform Decis Mak

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“…Studies focussing on BCG vaccination and cancer are summarized in Table 3. In the early 1970s, a decreased leukaemia mortality rate among individuals who had received neonatal BCG vaccination was reported (100, 101). This report triggered several reactions in the scientific community: some criticizing the methods (102, 103), others cautiously presenting somewhat convergent results (104, 105).…”

Section: Cancermentioning

confidence: 99%

Potential health effects from non‐specific stimulation of the immune function in early age: The example of BCG vaccination

Rousseau

Parent

St‐Pierre

2008

Pediatric Allergy Immunology

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There is increasing, but still inconsistent evidence that vaccinations and childhood infections may play a role in the normal maturation of the immune system, and in the development and balance of immune regulatory pathways, both of which might impact health later in life. This review covers the epidemiological evidence regarding the role of Bacillus Calmette-Guérin (BCG) vaccination on the following inflammatory or autoimmune diseases: asthma and allergic diseases, Crohn's disease (CD), insulin-dependent diabetes mellitus (IDDM), and specific cancers. The literature is more comprehensive for asthma and allergic diseases, with 16 studies reporting the absence of an association while seven rather suggest a protective effect of BCG. We found insufficient evidence on CD to conclude at this point. Overall, the evidence for IDDM based on four studies leans towards no association, although some effects were observed in population subsets. Five epidemiological investigations provide evidence on a possible link with cancer incidence or mortality at various sites, with indications of both increased and decreased risks. Given the potential public health implications, it is imperative to acquire a better understanding of how BCG vaccination could influence the development of such chronic health conditions in the population.

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“…Encouraged by these results, Israel 8?-84 conducted additional trials for squamous carcinoma of the lung, oat cell carcinoma of the lung, breast cancer, and soft tissue sarcomas. The results are presented in TABLE 9. For all tumor types, patients treated with C. parvum plus chemotherapy survived longer than did patients treated with chemotherapy alone.…”

Section: Systemic Chemoimmunotherapymentioning

confidence: 99%

Critical Review of Previously Reported Clinical Trials of Cancer Immunotherapy With Non‐specific Immunostimulants*

Mastrangelo

Berd

Bellet

1976

Annals of the New York Academy of Sciences

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B.C.G. Vaccination and Leukæmia Mortality

Cited by 32 publications

References 6 publications

The Québec BCG Vaccination Registry (1956–1992): assessing data quality and linkage with administrative health databases

The Québec BCG Vaccination Registry (1956–1992): assessing data quality and linkage with administrative health databases

Potential health effects from non‐specific stimulation of the immune function in early age: The example of BCG vaccination

Critical Review of Previously Reported Clinical Trials of Cancer Immunotherapy With Non‐specific Immunostimulants*

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