B(C₆F₅)₃-catalyzed regio- and stereoselective thiosulfonylation of terminal alkynes with thiosulfonates

Abstract

Herein, a metal-free main-group catalysis system for thiosulfonylation of terminal alkynes with thiosulfonates has been eatablished by using commercial available B(C6F5)3 as catalyst. The protocol provides a highly regio- and...

Regio- and Stereoselective Intermolecular 1,2-Difunctionalization of Terminal Alkynes: An Approach to Access (Z)-β-Amidovinylsulfones

“…These existing approaches are restricted to the addition of aryl sulfones, the presynthesis of enamide substrates, and multistep reactions. − Nowadays, intermolecular regioselective 1,2-difunctionalization of alkynes is a potent tool for upgrading feedstocks into molecules because it permits the simultaneous installation of two vicinal new bonds. Several approaches including hydrosulfonylation, aminosulfonylation, carbosulfonylation, oxysulfonylation, thiosulfonylation, seleno-sulfonylation, and halosulfonylation have been developed for the synthesis of these sulfonylated compounds. In 2017, Bi et al reported an intermolecular radical reaction using silver catalyst for the synthesis of aminosulfonylation of alkynes (Scheme b) .…”