2020
DOI: 10.34172/ps.2020.60
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Carnosine Mitigates Biomarkers of Oxidative Stress, Improves Mitochondrial Function, and Alleviates Histopathological Alterations in the Renal Tissue of Cholestatic Rats

Abstract: Background: Cholestatic liver disease primarily affects hepatic tissue. Cholestasis could also influence the function of other organs rather than the liver. Cholestasis-induced kidney injury is a severe clinical complication known as "cholemic nephropathy" (CN). Bile duct ligation (BDL) is a trustworthy experimental model for inducing CN. Although the precise mechanism of renal injury in cholestasis is not fully recognized, several studies revealed the role of oxidative stress in CN. There is no promising phar… Show more

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Cited by 9 publications
(5 citation statements)
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“…Cholestasis is a multifaceted clinical complication that could affect many organs [18,33,54,[70][71][72]. Although the liver is the primary organ injured by cholestasis, a plethora of evidence indicates cholestasis-induced renal, brain, and heart injuries [18].…”
Section: Discussionmentioning
confidence: 99%
“…Cholestasis is a multifaceted clinical complication that could affect many organs [18,33,54,[70][71][72]. Although the liver is the primary organ injured by cholestasis, a plethora of evidence indicates cholestasis-induced renal, brain, and heart injuries [18].…”
Section: Discussionmentioning
confidence: 99%
“…The ROS contents of the hippocampus and cerebral cortex were evaluated by dichlorofluorescein diacetate (DCFH-DA; 10 μM final concentration) as the fluorescent probe. In brief, DCFH-DA was added to homogenized specimens (1 mg of protein/mL) and incubated for 30 min at 35 °C in the dark. Afterward, the DCF fluorescence intensity at λ excitation = 485 nm and λ emission = 525 nm was documented using a FLUOstar Omega multifunctional microplate reader (BMG LABTECH, Germany). …”
Section: Methodsmentioning
confidence: 99%
“…The differential centrifugation method was used to isolate kidney mitochondria (85)(86)(87)(88)(89). For this purpose, mice kidneys…”
Section: Kidney Mitochondria Isolationmentioning
confidence: 99%