2016
DOI: 10.1161/atvbaha.116.307559
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B-Cell Depletion Promotes Aortic Infiltration of Immunosuppressive Cells and Is Protective of Experimental Aortic Aneurysm

Abstract: Objective B cell depletion therapy is widely used for treatment of cancers and autoimmune diseases. B cells are abundant in abdominal aortic aneurysms (AAA), however, it is unknown whether B cell depletion therapy affects AAA growth. Using experimental models of murine AAA, we aim to examine the effect of B cell depletion on AAA formation. Approach and Results Wild-type or Apolipoprotein E knockout mice were treated with mouse monoclonal anti-CD20 or control antibodies and subjected to an elastase perfusion … Show more

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Cited by 60 publications
(61 citation statements)
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“…In Apoe ‐deficient or Ldlr ‐deficient hyperlipidemic mice, AAA can be induced with a continuous infusion of angiotensin II. Our finding that B cells were required for the full development of AAA after CaCl 2 challenge was consistent with previous reports that showed that muMT mice were protected from elastase‐induced AAA and that B cell depletion by anti‐CD20 antibody abrogated AAA development induced by angiotensin II in Apoe ‐deficient mice . On the other hand, a state of total lymphocyte deficiency attenuated atherosclerosis in Apoe ‐deficient mice but not angiotensin II–induced AAA; furthermore, muMT mice were not protected from elastase‐induced AAA .…”
Section: Discussionsupporting
confidence: 92%
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“…In Apoe ‐deficient or Ldlr ‐deficient hyperlipidemic mice, AAA can be induced with a continuous infusion of angiotensin II. Our finding that B cells were required for the full development of AAA after CaCl 2 challenge was consistent with previous reports that showed that muMT mice were protected from elastase‐induced AAA and that B cell depletion by anti‐CD20 antibody abrogated AAA development induced by angiotensin II in Apoe ‐deficient mice . On the other hand, a state of total lymphocyte deficiency attenuated atherosclerosis in Apoe ‐deficient mice but not angiotensin II–induced AAA; furthermore, muMT mice were not protected from elastase‐induced AAA .…”
Section: Discussionsupporting
confidence: 92%
“…On the other hand, a state of total lymphocyte deficiency attenuated atherosclerosis in Apoe ‐deficient mice but not angiotensin II–induced AAA; furthermore, muMT mice were not protected from elastase‐induced AAA . A potential explanation for these controversial results could be that T cells participated in AAA pathogenesis by modulating the effect of B cells . For example, the deletion of all T cells has been reported to abrogate the effect of regulatory T cells in suppressing AAA formation in an angiotensin II–induced model .…”
Section: Discussionmentioning
confidence: 99%
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“…37 Consistent with this finding, Ailawadi’s group reported that depletion of B cells by anti-CD20 antibody reduced AAA in both AngII-induced and elastase-induced AAA models. 42 …”
Section: Abdominal Aortic Aneurysmsmentioning
confidence: 99%