B-cell differentiation pattern of cutaneous lymphomas in infancy and childhood

Abstract

This article documents four children with cutaneous lymphomas. Two of them had regional disease and the other two already had disseminated disease when they were diagnosed. Immunophenotyping of the lymphomatous infiltration disclosed a cell antigen profile with pre-pre-B (HLA-DR+, CALLA+, VIB-C5+), pre-B (HLADR+, CALLA+, VIB-C5+, cytoplasmatic immunoglobulin+), and transitional pre-B characteristics (HLA-DR+, CALLA+, VIB-C5+, surface immunoglobulin+). The morphology of the blast cells in all patients showed features of lymphoblastic lymphoma. Two patients had the convoluted cell type in common, but they were immunologically different, one displaying pre-pre-B and the other pre-B immunophenotypes. The remaining two cases were diagnosed as lymphoblastic lymphomas "type others" according to the Kiel Classification, one with pre-B and the other with transitional pre-B characteristics. The morphologic and immunohistochemical parameters as well as the clinical data from the four cases clearly indicate the heterogeneity of cutaneous non-Hodgkin's lymphomas in children.

Precursor B-cell lymphoblastic lymphoma in childhood and adolescence: Clinical features, treatment, and results in trials NHL-BFM 86 and 90

“…Bone, soft tissue, and visceral organs can all be involved. A more distinct feature is subcutaneous infiltration, especially of the head, as previously reported by others [30][31][32][33][34].…”

Precursor B cell lymphoblastic lymphoma presenting as periorbital swelling

“…The median age of diagnosis in precursor B cell LBL is 8 years and there is no difference in gender distribution 4. T cell LBL commonly presents with a mediastinal mass in comparison with precursor B cell LBL, in which the skin, head, neck, bone and lymph nodes are mainly involved 5 6…”

Cutaneous Lymphoblastic Lymphomas

“…Children and young adults are usually affected, but cases in neonates have been also observed [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. Clinically patients present with large erythematous tumors, usually solitary, commonly located on the head and neck ( Fig.…”